Romiti GF, Corica B, Proietti M, Mei DA, Frydenlund J, Bisson A, Boriani G, Olshansky B, Chan YH, Huisman MV, Chao TF, Lip GY, Abban DW, Abdul N, Abud AM, Adams F, Addala S, Adragão P, Ageno W, Aggarwal R, Agosti S, Agostoni P, Aguilar F, Linares JA, Aguinaga L, Ahmed J, Aiello A, Ainsworth P, Aiub JR, Al-Dallow R, Alderson L, Aldrete Velasco JA, Alexopoulos D, Manterola FA, Aliyar P, Alonso D, Alves da Costa FA, Amado J, Amara W, Amelot M, Amjadi N, Ammirati F, Andrade M, Andrawis N, Annoni G, Ansalone G, Ariani MK, Arias JC, Armero S, Arora C, Aslam MS, Asselman M, Audouin P, Augenbraun C, Aydin S, Ayryanova I, Aziz E, Backes LM, Badings E, Bagni E, Baker SH, Bala R, Baldi A, Bando S, Banerjee S, Bank A, Esquivias GB, Barr C, Bartlett M, Kes VB, Baula G, Behrens S, Bell A, Benedetti R, Mazuecos JB, Benhalima B, Bergler-Klein J, Berneau JB, Bernstein RA, Berrospi P, Berti S, Berz A, Best E, Bettencourt P, Betzu R, Bhagwat R, Bhatta L, Biscione F, Bisignani G, Black T, Bloch MJ, Bloom S, Blumberg E, Bo M, Bøhmer E, Bollmann A, Bongiorni MG, Boswijk DJ, Bott J, Bottacchi E, Kalan MB, Bradman D, Brautigam D, Breton N, Brouwers PJ, Browne K, Cortada JB, Bruni A, Brunschwig C, Buathier H, Buhl A, Bullinga J, Cabrera JW, Caccavo A, Cai S, Caine S, Calò L, Calvi V, Sánchez MC, Candeias R, Capuano V, Capucci A, Caputo R, Rizo TC, Cardona F, Carlos da Costa Darrieux F, Duarte Vera YC, Carolei A, Carreño S, Carvalho P, Cary S, Casu G, Cavallini C, Cayla G, Celentano A, Cha TJ, Cha KS, Chae JK, Chalamidas K, Challappa K, Chand SP, Chandrashekar H, Chartier L, Chatterjee K, Chavez Ayala CA, Cheema A, Cheema A, Chen L, Chen SA, Chen JH, Chiang FT, Chiarella F, Chih-Chan L, Cho YK, Choi JI, Choi DJ, Chouinard G, Hoi-Fan Chow D, Chrysos D, Chumakova G, José Roberto EJ, Valenzuela C, Nica NC, Cislowski DJ, Clay A, Clifford P, Cohen A, Cohen M, Cohen S, Colivicchi F, Collins R, Colonna P, Compton S, Connolly D, Conti A, Buenostro GC, Coodley G, Cooper M, Coronel J, Corso G, Sales JC, Cottin Y, Covalesky J, Cracan A, Crea F, Crean P, Crenshaw J, Cullen T, Darius H, Dary P, Dascotte O, Dauber I, Davalos V, Davies R, Davis G, Davy JM, Dayer M, De Biasio M, De Bonis S, De Caterina R, De Franceschi T, de Groot JR, De Horta J, De La Briolle A, Topete GdlP, Vicenzo de Paola AA, de Souza W, de Veer A, De Wolf L, Decoulx E, Deepak S, Defaye P, Del-Carpio Munoz F, Brkljacic DD, Deumite NJ, Di Legge S, Diemberger I, Dietz D, Dionísio P, Dong Q, Rossi dos Santos F, Dotcheva E, Doukky R, D'Souza A, Dubrey S, Ducrocq X, Dupljakov D, Duque M, Dutta D, Duvilla N, Duygun A, Dziewas R, Eaton CB, Eaves W, Ebels-Tuinbeek; Clifford Ehrlich LA, Eichinger-Hasenauer S, Eisenberg SJ, El Jabali A, El Shahawy M, Hernandes ME, Izal AE, Evonich R, Evseeva O, Ezhov A, Fahmy R, Fang Q, Farsad R, Fauchier L, Favale S, Fayard M, Fedele JL, Fedele F, Fedorishina O, Fera SR, Gomes Ferreira LG, Ferreira J, Ferri C, Ferrier A, Ferro H, Finsen A, First B, Fischer S, Fonseca C, Almeida LF, Forman S, Frandsen B, French W, Friedman K, Friese A, Fruntelata AG, Fujii S, Fumagalli S, Fundamenski M, Furukawa Y, Gabelmann M, Gabra N, Gadsbøll N, Galinier M, Gammelgaard A, Ganeshkumar P, Gans C, Quintana AG, Gartenlaub O, Gaspardone A, Genz C, Georger F, Georges JL, Georgeson S, Giedrimas E, Gierba M, Ortega IG, Gillespie E, Giniger A, Giudici MC, Gkotsis A, Glotzer TV, Gmehling J, Gniot J, Goethals P, Goldbarg S, Goldberg R, Goldmann B, Golitsyn S, Gómez S, Mesa JG, Gonzalez VB, Gonzalez Hermosillo JA, González López VM, Gorka H, Gornick C, Gorog D, Gottipaty V, Goube P, Goudevenos I, Graham B, Greer GS, Gremmler U, Grena PG, Grond M, Gronda E, Grönefeld G, Gu X, Torres Torres IG, Guardigli G, Guevara C, Guignier A, Gulizia M, Gumbley M, Günther A, Ha A, Hahalis G, Hakas J, Hall C, Han B, Han S, Hargrove J, Hargroves D, Harris KB, Haruna T, Hayek E, Healey J, Hearne S, Heffernan M, Heggelund G, Heijmeriks JA, Hemels M, Hendriks I, Henein S, Her SH, Hermany P, Hernández Del Río JE, Higashino Y, Hill M, Hisadome T, Hishida E, Hoffer E, Hoghton M, Hong K, Hong Sk, Horbach S, Horiuchi M, Hou Y, Hsing J, Huang CH, Huckins D, Hughes k, Huizinga A, Hulsman EL, Hung KC, Hwang GS, Ikpoh M, Imberti D, Ince H, Indolfi C, Inoue S, Irles D, Iseki H, Israel CN, Iteld B, Iyer V, Jackson-Voyzey E, Jaffrani N, Jäger F, James M, Jang SW, Jaramillo N, Jarmukli N, Jeanfreau RJ, Jenkins RD, Sánchez CJ, Jimenez J, Jobe R, Joen-Jakobsen T, Jones N, Moura Jorge JC, Jouve B, Jung BC, Jung KT, Jung W, Kachkovskiy M, Kafkala K, Kalinina L, Kallmünzer B, Kamali F, Kamo T, Kampus P, Kashou H, Kastrup A, Katsivas A, Kaufman E, Kawai K, Kawajiri K, Kazmierski JF, Keeling P, Kerr Saraiva JF, Ketova G, Khaira AS, Khripun A, Kim DI, Kim YH, Kim NH, Kim DK, Kim JS, Kim JS, Kim KS, Kim Jb, Kinova E, Klein A, Kmetzo JJ, Kneller GL, Knezevic A, Angela Koh SM, Koide S, Kollias A, Kooistra JA, Koons J, Koschutnik M, Kostis WJ, Kovacic D, Kowalczyk J, Koziolova N, Kraft P, Kragten JA, Krantz M, Krause L, Krenning BJ, Krikke F, Kromhout Z, Krysiak W, Kumar P, Kümler T, Kuniss M, Kuo JY, Küppers A, Karla Kurrelmeyer , Kwak CH, Laboulle B, Labovitz A, Lai WT, Lam A, Lam YY, Zanetti FL, Landau C, Landini G, Figueiredo EL, Larsen T, Lavandier K, LeBlanc J, Lee MH, Lee CH, Lehman J, Leitão A, Lellouche N, Lelonek M, Lenarczyk R, Lenderink T, González SL, Leong-Sit P, Leschke M, Ley N, Li Z, Li X, Li W, Li X, Lichy C, Lieber I, Limon Rodriguez RH, Lin H, Liu F, Liu H, Esperon GL, Navarro NL, Lo E, Lokshyn S, López A, López-Sendón JL, Lorga Filho AM, Lorraine RS, Luengas CA, Luke R, Luo M, Lupovitch S, Lyrer P, Ma C, Ma G, Madariaga I, Maeno K, Magnin D, Maid G, Mainigi SK, Makaritsis K, Malhotra R, Manning R, Manolis A, Manrique Hurtado HA, Mantas I, Jattin FM, Maqueda V, Marchionni N, Ortuno FM, Santana AM, Martinez J, Maskova P, Hernandez NM, Matsuda K, Maurer T, Mauro C, May E, Mayer N, McClure J, McCormack T, McGarity W, McIntyre H, McLaurin B, Medina Palomino FA, Melandri F, Meno H, Menzies D, Mercader M, Meyer C, Meyer BJ, Miarka J, Mibach F, Michalski D, Michel P, Chreih RM, Mikdadi G, Mikus M, Milicic D, Militaru C, Minaie S, Minescu B, Mintale I, Mirault T, Mirro MJ, Mistry D, Miu NV, Miyamoto N, Moccetti T, Mohammed A, Nor AM, Mollerus M, Molon G, Mondillo S, Moniz P, Mont L, Montagud V, Montaña O, Monti C, Moretti L, Mori K, Moriarty A, Morka J, Moschini L, Moschos N, Mügge A, Mulhearn TJ, Muresan C, Muriago M, Musial W, Musser CW, Musumeci F, Nageh T, Nakagawa H, Nakamura Y, Nakayama T, Nam GB, Nanna M, Natarajan I, Nayak HM, Naydenov S, Nazlić J, Cristian Nechita A, Nechvatal L, Negron SA, Neiman J, Neuenschwander FC, Neves D, Neykova A, Miguel RN, Nijmeh G, Nizov A, Campos RN, Nossan J, Novikova T, Nowalany-Kozielska E, Nsah E, Nunez Fragoso JC, Nurgalieva S, Nuyens D, Nyvad O, Odin de Los Rios Ibarra M, O'Donnell P, O'Donnell M, Oh S, Oh YS, Oh D, O'Hara G, Oikonomou K, Olivares C, Oliver R, Ruiz RO, Olympios C, omaszuk-Kazberuk A, Asensi JO, Jose eP, Padilla Padilla FG, Rios VP, Pajes G, Pandey S, Paparella G, Paris F, Park HW, Park JS, Parthenakis F, Passamonti E, Patel RJ, Patel J, Patel M, Patrick J, Jimenez RP, Paz A, Pengo V, Pentz W, Pérez B, Pérez Ríos AM, Pérez-Cabezas A, Perlman R, Persic V, Perticone F, Peters TK, Petkar S, Pezo LF, Pflücke C, Pham DN, Phillips RT, Phlaum S, Pieters D, Pineau J, Pinter A, Pinto F, Pisters R, Pivac N, Pocanic D, Podoleanu C, Politano A, Poljakovic Z, Pollock S, Garcéa JP, Poppert H, Porcu M, Reino AP, Prasad N, Précoma DB, Prelle A, Prodafikas J, Protasov K, Pye M, Qiu Z, Quedillac JM, Raev D, Raffo Grado CA, Rahimi S, Raisaro A, Rama B, Ramos R, Ranieri M, Raposo N, Rashba E, Rauch-Kroehnert U, Reddy R, Renda G, Reza S, Ria L, Richter D, Rickli H, Rieker W, Vera TR, Ritt LE, Roberts D, Briones IR, Rodriguez Escudero AE, Pascual CR, Roman M, Romeo F, Ronner E, Roux JF, Rozkova N, Rubacek M, Rubalcava F, Russo AM, Rutgers MP, Rybak K, Said S, Sakamoto T, Salacata A, Salem A, Bodes RS, Saltzman MA, Salvioni A, Vallejo GS, Fernández MS, Saporito WF, Sarikonda K, Sasaoka T, Sati H, Savelieva I, Scala PJ, Schellinger P, Scherr C, Schmitz L, Schmitz KH, Schmitz B, Schnabel T, Schnupp S, Schoeniger P, Schön N, Schwimmbeck P, Seamark C, Searles G, Seidl KH, Seidman B, Sek J, Sekaran L, Serrati C, Shah N, Shah V, Shah A, Shah S, Sharma VK, Shaw L, Sheikh KH, Shimizu N, Shimomura H, Shin DG, Shin ES, Shite J, Sibilio G, Silver F, Sime I, Simmers TA, Singh N, Siostrzonek P, Smadja D, Smith DW, Snitman M, Filho DS, Soda H, Sofley C, Sokal A, Oi Yan YS, Sotolongo R, Ferreira de Souza O, Sparby JA, Spinar J, Sprigings D, Spyropoulos AC, Stakos D, Steinwender C, Stergiou G, Stiell I, Stoddard M, Stoikov A, Streb W, Styliadis I, Su G, Su X, Sudnik W, Sukles K, Sun X, Swart H, Szavits-Nossan J, Taggeselle J, Takagi Y, Singh Takhar AP, Tamm A, Tanaka K, Tanawuttiwat T, Tang S, Tang A, Tarsi G, Tassinari T, Tayal A, Tayebjee M, Berg JM, Tesloianu D, The SH, Thomas D, Timsit S, Tobaru T, Tomasik AR, Torosoff M, Touze E, Trendafilova E, Tsai WK, Tse HF, Tsutsui H, Tu TM, Tuininga Y, Turakhia M, Turk S, Turner W, Tveit A, Tytus R, Valadão C, van Bergen PF, van de Borne P, van den Berg BJ, van der Zwaan C, Van Eck M, Vanacker P, Vasilev D, Vasilikos V, Vasilyev M, Veerareddy S, Miño; Asok Venkataraman MV, Verdecchia P, Versaci F, Vester EG, Vial H, Victory J, Villamil A, Vincent M, Vlastaris A, Dahl Jv, Vora K, Vranian RB, Wakefield P, Wang N, Wang M, Wang X, Wang F, Wang T, Warner AL, Watanabe K, Wei J, Weimar C, Weiner S, Weinrich R, Wen MS, Wiemer M, Wiggers P, Wilke A, Williams D, Williams ML, Witzenbichler B, Wong B, Lawrence Wong KS, Wozakowska-Kaplon B, Wu S, Wu RC, Wunderlich S, Wyatt N, Wylie J, Xu Y, Xu X, Yamanoue H, Yamashita T, Bryan Yan PY, Yang T, Yao J, Yeh KH, Yin WH, Yotov Y, Zahn R, Zarich S, Zenin S, Zeuthen EL, Zhang H, Zhang D, Zhang X, Zhang P, Zhang J, Zhao SP, Zhao Y, Zhao Z, Zheng Y, Zhou J, Zimmermann S, Zini A, Zizzo S, Zong W, Zukerman LS (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 63
DOI: 10.1016/j.eclinm.2023.102039
BACKGROUND: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. METHODS: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. FINDINGS: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. INTERPRETATION: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. FUNDING: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH.
APA:
Romiti, G.F., Corica, B., Proietti, M., Mei, D.A., Frydenlund, J., Bisson, A.,... Zukerman, L.S. (2023). Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry. EClinicalMedicine, 63. https://dx.doi.org/10.1016/j.eclinm.2023.102039
MLA:
Romiti, Giulio Francesco, et al. "Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry." EClinicalMedicine 63 (2023).
BibTeX: Download