Enthesitis in patients with psoriatic arthritis treated with secukinumab or adalimumab: a post hoc analysis of the EXCEED study.
Kaeley GS, Schett G, Conaghan PG, McGonagle D, Behrens F, Goupille P, Gaillez C, Parikh B, Bakewell C (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 63
Pages Range: 41-49
Journal Issue: 1
DOI: 10.1093/rheumatology/kead181
Abstract
OBJECTIVES: To evaluate enthesitis treatment response, including time to resolution and data from multiple enthesitis instruments, in patients with PsA treated with secukinumab or adalimumab for 52 weeks. METHODS: In this post hoc analysis of the EXCEED study, patients receiving secukinumab 300 mg or adalimumab 40 mg per the label were grouped by presence or absence of baseline enthesitis based on the Leeds Enthesitis Index (LEI) and the Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC). Efficacy was assessed according to several enthesitis-related instruments using non-responder imputation for the achievement of enthesitis resolution (LEI/SPARCC = 0), Kaplan-Meier analysis for time to resolution, and as-observed data for other outcomes. RESULTS: Enthesitis was present at baseline in 498 of 851 patients (58.5%) as assessed by LEI and in 632 of 853 patients (74.1%) as assessed by SPARCC. Patients with baseline enthesitis generally presented with greater disease activity. Similar proportions of patients receiving secukinumab or adalimumab achieved resolution of LEI and SPARCC at weeks 24 (secukinumab: LEI/SPARCC, 49.6%/45.8%; adalimumab: LEI/SPARCC, 43.6%/43.5%) and 52 (secukinumab: LEI/SPARCC, 60.7%/53.2%; adalimumab: LEI/SPARCC, 55.3%/51.4%), with comparable mean time to enthesitis resolution. Improvements were similar for both drugs at individual enthesitis sites. Resolution of enthesitis with secukinumab or adalimumab was associated with improvements in quality of life at week 52. CONCLUSION: Secukinumab and adalimumab showed similar efficacy, including time to resolution, with respect to resolution of enthesitis. Inhibition of IL-17 with secukinumab reduced clinical enthesitis similarly to TNF-α inhibition. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02745080.
Authors with CRIS profile
Involved external institutions
University of Florida
United States (USA) (US)
Intermountain Healthcare
United States (USA) (US)
University of Leeds
United Kingdom (GB)
Goethe-Universität Frankfurt am Main
Germany (DE)
Centre Hospitalier Régional Universitaire de Tours
France (FR)
Novartis AG
Switzerland (CH)
AbbVie Inc.
United States (USA) (US)
United States (USA) (US)
Intermountain Healthcare
United States (USA) (US)
University of Leeds
United Kingdom (GB)
Goethe-Universität Frankfurt am Main
Germany (DE)
Centre Hospitalier Régional Universitaire de Tours
France (FR)
Novartis AG
Switzerland (CH)
AbbVie Inc.
United States (USA) (US)
How to cite
APA:
Kaeley, G.S., Schett, G., Conaghan, P.G., McGonagle, D., Behrens, F., Goupille, P.,... Bakewell, C. (2024). Enthesitis in patients with psoriatic arthritis treated with secukinumab or adalimumab: a post hoc analysis of the EXCEED study. Rheumatology, 63(1), 41-49. https://dx.doi.org/10.1093/rheumatology/kead181
MLA:
Kaeley, Gurjit S., et al. "Enthesitis in patients with psoriatic arthritis treated with secukinumab or adalimumab: a post hoc analysis of the EXCEED study." Rheumatology 63.1 (2024): 41-49.
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