Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease

Träger AP, Günther J, Raming R, Paulus LP, Lang W, Meyer A, Kempf J, Caranovic M, Li Y, Wagner A, Tan L, Danko V, Trollmann R, Wölfle J, Klett D, Neurath M, Regensburger A, Eckstein M, Uter W, Uder M, Herrmann Y, Waldner M, Knieling F, Rother U (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Photoacoustics Elsevier

Book Volume: 35

Article Number: 100579

DOI: 10.1016/j.pacs.2023.100579

Abstract

Peripheral arterial disease (PAD) leads to chronic vascular occlusion and results in end organ damage in critically perfused limbs. There are currently no clinical methods available to determine the muscular damage induced by chronic mal-perfusion. This monocentric prospective cross-sectional study investigated n = 193 adults, healthy to severe PAD, in order to quantify the degree of calf muscle degeneration caused by PAD using a non-invasive hybrid ultrasound and single wavelength optoacoustic imaging (US/SWL-OAI) approach. While US provides morphologic information, SWL-OAI visualizes the absorption of pulsed laser light and the resulting sound waves from molecules undergoing thermoelastic expansion. US/SWL-OAI was compared to multispectral data, clinical disease severity, angiographic findings, phantom experiments, and histological examinations from calf muscle biopsies. We were able to show that synergistic use of US/SWL-OAI is most likely to map clinical degeneration of the muscle and progressive PAD.

Authors with CRIS profile

Josefine Günther Department of Vascular Surgery Roman Raming Department of Paediatrics and Adolescent Medicine Lars-Philip Paulus Lehrstuhl für Kinder- und Jugendmedizin Werner Lang Department of Vascular Surgery Alexander Meyer Department of Vascular Surgery Julius Kempf Department of Vascular Surgery Yi Li Department of Vascular Surgery Alexandra Wagner Professur für Kinder- u. Jugendmedizin Schwerpunkt Neuropädiatrie Regina Trollmann Medizinische Fakultät Joachim Wölfle Lehrstuhl für Kinder- und Jugendmedizin Daniel Klett Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Markus Neurath Lehrstuhl für Innere Medizin I Adrian Regensburger Department of Paediatrics and Adolescent Medicine Markus Eckstein Institute of Pathology Wolfgang Uter Professur für Epidemiologie Michael Uder Lehrstuhl für Diagnostische Radiologie Maximilian Waldner Lehrstuhl für Innere Medizin I Ferdinand Knieling Department of Paediatrics and Adolescent Medicine Ulrich Rother Department of Vascular Surgery

How to cite

APA:

Träger, A.P., Günther, J., Raming, R., Paulus, L.-P., Lang, W., Meyer, A.,... Rother, U. (2024). Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease. Photoacoustics, 35. https://doi.org/10.1016/j.pacs.2023.100579

MLA:

Träger, Anna P., et al. "Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease." Photoacoustics 35 (2024).

BibTeX: Download