High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics

Richter M, Loth Y, Wigger AK, Nordhoff D, Rachinger N, Weisenstein C, Boßerhoff AK, Bolívar PH (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 13

Article Number: 20708

Journal Issue: 1

DOI: 10.1038/s41598-023-46876-5

Abstract

In this work, we present a promising diagnostic tool for melanoma diagnosis. With the proposed terahertz biosensor, it was possible to selectively and sensitively detect the early growth response protein 2, a transcription factor with an increased activity in melanoma cells, from a complex sample of cellular proteins. Fundamentally, the sensor belongs to the frequency selective surface type metamaterials and consists of a two-dimensional array of asymmetrically, doubly split ring resonator unit cells. The single elements are slits in a metallic layer and are complemented by an undercut etch. This allows a selective functionalization of the active area of the sensor and increases the sensitivity towards the target analyte. Hereby, specific detection of a defined transcription factor is feasible.

Authors with CRIS profile

Nicole Rachinger Lehrstuhl für Biochemie und Molekulare Medizin Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Universität Siegen DE Germany (DE)

How to cite

APA:

Richter, M., Loth, Y., Wigger, A.K., Nordhoff, D., Rachinger, N., Weisenstein, C.,... Bolívar, P.H. (2023). High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics. Scientific Reports, 13(1). https://dx.doi.org/10.1038/s41598-023-46876-5

MLA:

Richter, Merle, et al. "High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics." Scientific Reports 13.1 (2023).

BibTeX: Download