Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps

Müller-Hübner S, Wendler O, Mayr S, Traxdorf M, Koch M, Mantsopoulos K, Sievert M, Grundtner P, Iro H, Bleier BS (2023)

Publication Type: Journal article

Publication year: 2023

Journal

International Forum of Allergy and Rhinology Wiley-VCH Verlag

DOI: 10.1002/alr.23295

Abstract

Objective: The objective of this study was to analyze advantages and disadvantages of mucus and serum for biomarker analysis. Methods: This study includes prospective study of 61 CRS with nasal polyps patients who were followed over 24 months and over nine time points after functional endoscopic sinus surgery. At each time points, the nasal polyp score (NPS) was assessed and mucus as well as serum was collected. Selected were measured in mucus and serum. Mean, standard deviation and variance, undetectable values, and the correlation of the biomarkers to the NPS over time and to early recurrences were calculated, and the effect of surgery on the biomarkers was assessed. Additionally, the diurnal rhythm of all biomarkers was measures in order to assure stable biomarker values during sampling times. Results: All biomarkers showed stable values during sampling times. Serum biomarker levels displayed higher percentages of undetectable values compared to mucus biomarkers. Mucus periostin (p < 0.001, r = 0.89), mucus IgE (p < 0.001, r = 0.51), serum periostin (p < 0.001, r = 0.53), mucus CST1 (p < 0.001, r = 0.27), and serum IgE (p < 0.01, r = −0.18) were the best marker and medium combinations to track the NPS over time and to predict recurrences. Mucus serpinF2 was negatively correlated and predicted early recurrences (p = 0.026, R2 = 0.015). Conclusions: Serum and mucus both represent viable mediums for “liquid biopsies.” The most promising biomarker/medium combinations over time to track disease severity were mucus periostin, mucus IgE, serum periostin, mucus CST1, and serum IgE. Mucus serpinF2 was the best biomarker to predict early recurrences.

Authors with CRIS profile

Sarina Müller-Hübner Department of Otorhinolaryngology – Head and Neck Surgery Olaf Wendler Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Maximilian Traxdorf Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Michael Koch Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Konstantinos Mantsopoulos Department of Otorhinolaryngology – Head and Neck Surgery Matti Sievert Department of Otorhinolaryngology – Head and Neck Surgery Heinrich Iro Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde

Involved external institutions

Veterans Affairs Healthcare System Boston and Harvard Medical School US United States (USA) (US)

How to cite

APA:

Müller-Hübner, S., Wendler, O., Mayr, S., Traxdorf, M., Koch, M., Mantsopoulos, K.,... Bleier, B.S. (2023). Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps. International Forum of Allergy and Rhinology. https://doi.org/10.1002/alr.23295

MLA:

Müller-Hübner, Sarina, et al. "Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps." International Forum of Allergy and Rhinology (2023).

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