Th2-dependent disappearance and phenotypic conversion of mouse alveolar macrophages

Dietschmann A, Ruhl A, Murray PJ, Günther C, Becker C, Fallon P, Vöhringer D (2023)

Publication Type: Journal article

Publication year: 2023

Journal

European Journal of Immunology Wiley-VCH Verlag

Book Volume: 53

Article Number: 2350475

Journal Issue: 10

DOI: 10.1002/eji.202350475

Abstract

Alveolar macrophages (alvMs) play an important role for maintenance of lung function by constant removal of cellular debris in the alveolar space. They further contribute to defense against microbial or viral infections and limit tissue damage during acute lung injury. alvMs arise from embryonic progenitor cells, seed the alveoli before birth, and have life-long self-renewing capacity. However, recruited monocytes may also help to restore the alvM population after depletion caused by toxins or influenza virus infection. At present, the population dynamics and cellular plasticity of alvMs during allergic lung inflammation is poorly defined. To address this point, we used a mouse model of Aspergillus fumigatus-induced allergic lung inflammation and observed that Th2-derived IL-4 and IL-13 caused almost complete disappearance of alvMs. This effect required STAT6 expression in alvMs and also occurred in various other settings of type 2 immunity-mediated lung inflammation or administration of IL-4 complexes to the lung. In addition, Th2 cells promoted conversion of alvMs to alternatively activated macrophages and multinucleated giant cells. Given the well-established role of alvMs for maintenance of lung function, this process may have implications for resolution of inflammation and tissue homeostasis in allergic asthma.

Authors with CRIS profile

Axel Dietschmann Department of Infection Biology Andreas Ruhl Department of Infection Biology Claudia Günther Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Christoph Becker Professur für Molekulare Gastroenterologie David Vöhringer Department of Infection Biology

Involved external institutions

Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry DE Germany (DE) Trinity College Dublin IE Ireland (IE)

How to cite

APA:

Dietschmann, A., Ruhl, A., Murray, P.J., Günther, C., Becker, C., Fallon, P., & Vöhringer, D. (2023). Th2-dependent disappearance and phenotypic conversion of mouse alveolar macrophages. European Journal of Immunology, 53(10). https://dx.doi.org/10.1002/eji.202350475

MLA:

Dietschmann, Axel, et al. "Th2-dependent disappearance and phenotypic conversion of mouse alveolar macrophages." European Journal of Immunology 53.10 (2023).

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