Pioneer factors in viral infection

Neugebauer E, Bastidas-Quintero AM, Weidl D, Full F (2023)

Publication Type: Journal article, Review article

Publication year: 2023


Book Volume: 14

Article Number: 1286617

DOI: 10.3389/fimmu.2023.1286617


Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing zygotic genome activation or cell fate decision. Some pioneer factors are actively induced or downregulated by viral infection. With this, viruses are capable to modulate different signaling pathways resulting for example in MHC-receptor up/downregulation which contributes to viral immune evasion. In this article, we review the current state of research on how different viruses (Herpesviruses, Papillomaviruses and Hepatitis B virus) use pioneer factors for their viral replication and persistence in the host, as well as for the development of viral cancer.

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Neugebauer, E., Bastidas-Quintero, A.M., Weidl, D., & Full, F. (2023). Pioneer factors in viral infection. Frontiers in Immunology, 14.


Neugebauer, Eva, et al. "Pioneer factors in viral infection." Frontiers in Immunology 14 (2023).

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