Pioneer factors in viral infection
Neugebauer E, Bastidas-Quintero AM, Weidl D, Full F (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Journal
Book Volume: 14
Article Number: 1286617
DOI: 10.3389/fimmu.2023.1286617
Abstract
Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing zygotic genome activation or cell fate decision. Some pioneer factors are actively induced or downregulated by viral infection. With this, viruses are capable to modulate different signaling pathways resulting for example in MHC-receptor up/downregulation which contributes to viral immune evasion. In this article, we review the current state of research on how different viruses (Herpesviruses, Papillomaviruses and Hepatitis B virus) use pioneer factors for their viral replication and persistence in the host, as well as for the development of viral cancer.
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Germany (DE)How to cite
APA:
Neugebauer, E., Bastidas-Quintero, A.M., Weidl, D., & Full, F. (2023). Pioneer factors in viral infection. Frontiers in Immunology, 14. https://dx.doi.org/10.3389/fimmu.2023.1286617
MLA:
Neugebauer, Eva, et al. "Pioneer factors in viral infection." Frontiers in Immunology 14 (2023).
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