Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Frontera JA, Guekht A, Allegri RF, Ashraf M, Baykan B, Crivelli L, Easton A, Garcia-Azorin D, Helbok R, Joshi J, Köhn J, Koralnik I, Netravathi M, Michael B, Nilo A, Özge A, Padda K, Pellitteri G, Prasad K, Romozzi M, Saylor D, Seed A, Thakur K, Uluduz D, Vogrig A, Welte T, Westenberg E, Zhuravlev D, Zinchuk M, Winkler AS (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Book Volume: 454

Article Number: 120827

DOI: 10.1016/j.jns.2023.120827

Abstract

Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020–4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.

Authors with CRIS profile

Involved external institutions

New York University (NYU) United States (USA) (US) Moscow Research and Clinical Center for Neuropsychiatry Russian Federation (RU) Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Argentina (AR) Weill Cornell Medicine United States (USA) (US) Istanbul University / İstanbul Üniversitesi Turkey (TR) Encephalitis Society United Kingdom (GB) Hospital Clínico Universitario de Valladolid / University Clinical Hospital of Valladolid Spain (ES) Medizinische Universität Innsbruck Austria (AT) Northwestern University United States (USA) (US) National Institute of Mental Health and Neuroscience (NIMHANS) India (IN) The University of Liverpool United Kingdom (GB) Ospedale Santa Maria della Misericordia di Udine Italy (IT) Mersin Üniversitesi (MEÜ) Turkey (TR) Rajendra Institute of Medical Sciences (RIMS) India (IN) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Italy (IT) Johns Hopkins University (JHU) United States (USA) (US) The Walton Centre NHS Foundation Trust United Kingdom (GB) Columbia University Irving Medical Center (CUIMC) United States (USA) (US) Klinikum rechts der Isar Germany (DE)

How to cite

APA:

Frontera, J.A., Guekht, A., Allegri, R.F., Ashraf, M., Baykan, B., Crivelli, L.,... Winkler, A.S. (2023). Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition. Journal of the Neurological Sciences, 454. https://dx.doi.org/10.1016/j.jns.2023.120827

MLA:

Frontera, Jennifer A., et al. "Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition." Journal of the Neurological Sciences 454 (2023).

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