Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection

Barmada A, Handfield LF, Godoy-Tena G, de la Calle-Fabregat C, Ciudad L, Arutyunyan A, Andrés-León E, Hoo R, Porter T, Oszlanczi A, Richardson L, Calero-Nieto FJ, Wilson NK, Marchese D, Sancho-Serra C, Carrillo J, Presas-Rodríguez S, Ramo-Tello C, Ruiz-Sanmartin A, Ferrer R, Ruiz-Rodriguez JC, Martínez-Gallo M, Munera-Campos M, Carrascosa JM, Göttgens B, Heyn H, Prigmore E, Casafont-Solé I, Solanich X, Sánchez-Cerrillo I, González-Álvaro I, Raimondo MG, Ramming A, Martin J, Martínez-Cáceres E, Ballestar E, Vento-Tormo1 R, Rodríguez-Ubreva J (2023)

Publication Type: Journal article

Publication year: 2023

Journal

European Journal of Immunology Wiley-VCH Verlag

DOI: 10.1002/eji.202350633

Abstract

In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection. We observed compositional differences between the autoimmune disease groups coupled with altered patterns of gene expression, transcription factor activity, and cell–cell communication that substantially shape the immune response under SARS-CoV-2 infection. While enrichment of HLA-DRlow CD14+ monocytes was observed in all three autoimmune disease groups, type-I interferon signaling as well as inflammatory T cell and monocyte responses varied widely between the three groups of patients. Our results reveal disturbed immune responses to SARS-CoV-2 in patients with pre-existing autoimmunity, highlighting important considerations for disease treatment and follow-up.

Authors with CRIS profile

Maria Gabriella Raimondo Department of Medicine 3 – Rheumatology and Immunology Andreas Ramming Professur für Immunologie der Organschädigung

Involved external institutions

Wellcome Trust Sanger Institute - Genome Research Limited GB United Kingdom (GB) Hospital Universitario de La Princesa ES Spain (ES) Josep Carreras Leukaemia Research Institute (IJC) ES Spain (ES) Health Sciences Research Institute of the “Germans Trias i Pujol” Foundation (IGTP) ES Spain (ES) Centre for Genomic Regulation (CRG) ES Spain (ES) University of Cambridge GB United Kingdom (GB) Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron ES Spain (ES) Institute of Parasitology and Biomedicine López-Neyra / Instituto de Parasitología y Biomedicina "López - Neyra" ES Spain (ES) Bellvitge University Hospital / Hospital Universitari de Bellvitge ES Spain (ES)

How to cite

APA:

Barmada, A., Handfield, L.F., Godoy-Tena, G., de la Calle-Fabregat, C., Ciudad, L., Arutyunyan, A.,... Rodríguez-Ubreva, J. (2023). Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection. European Journal of Immunology. https://doi.org/10.1002/eji.202350633

MLA:

Barmada, Anis, et al. "Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection." European Journal of Immunology (2023).

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