Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum
Fortmann C, Göen T, Wiesner S, Hegermann J, Kiblawi R, Dohna M, Ure BM, Renz DM, Petersen C, Kuebler JF (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 18
Article Number: e0292616
Journal Issue: 10 October
DOI: 10.1371/journal.pone.0292616
Abstract
Introduction Previous studies demonstrated a release of toxic metals, e.g. nickel and chromium, from stainless steel bars used for minimally invasive repair of pectus excavatum (MIRPE). In the present study, we investigated the impact of titanium nitride coating on the metal release and exposure of MIRPE patients. Material and methods We analyzed the courses of nickel and chromium levels in blood, urine and local tissue in patients undergoing MIRPE with a titanium nitride coated pectus bar between 03/2017 and 10/2018. Sample collection was scheduled prior to MIRPE, at defined postoperative time points and at bar removal. Additionally, we evaluated irritative symptoms. Results were compared to a control group who received uncoated stainless steel bars in a previous time period (03/2015-02/2017). Results 12 patients received coated pectus bars (mean age 15.7 years). The control group included 28 patients. After implantation of a titanium nitride coated bar, significant increase in systemic nickel and chromium levels after one, two and three years was noted. In an interim analysis one year after MIRPE, we observed patients with coated bars to have significantly elevated trace metal values compared to the control group. This elevation persisted throughout the observation period. Tissue metal values were also significantly increased. Irritative symptoms occurred significantly more often in study patients compared to controls (50.0% vs. 14.3%).
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Fortmann, C., Göen, T., Wiesner, S., Hegermann, J., Kiblawi, R., Dohna, M.,... Kuebler, J.F. (2023). Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum. PLoS ONE, 18(10 October). https://doi.org/10.1371/journal.pone.0292616
MLA:
Fortmann, Caroline, et al. "Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum." PLoS ONE 18.10 October (2023).
BibTeX: Download