Imaging in inflammatory arthritis: progress towards precision medicine

Minopoulou I, Kleyer A, Yalcin-Mutlu M, Fagni F, Kemenes S, Schmidkonz C, Atzinger A, Pachowsky M, Engel K, Folle L, Roemer F, Waldner M, D’Agostino MA, Schett G, Simon D (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Nature Reviews Rheumatology Nature Publishing Group

Book Volume: 19

Pages Range: 650-665

Journal Issue: 10

DOI: 10.1038/s41584-023-01016-1

Abstract

Imaging techniques such as ultrasonography and MRI have gained ground in the diagnosis and management of inflammatory arthritis, as these imaging modalities allow a sensitive assessment of musculoskeletal inflammation and damage. However, these techniques cannot discriminate between disease subsets and are currently unable to deliver an accurate prediction of disease progression and therapeutic response in individual patients. This major shortcoming of today’s technology hinders a targeted and personalized patient management approach. Technological advances in the areas of high-resolution imaging (for example, high-resolution peripheral quantitative computed tomography and ultra-high field MRI), functional and molecular-based imaging (such as chemical exchange saturation transfer MRI, positron emission tomography, fluorescence optical imaging, optoacoustic imaging and contrast-enhanced ultrasonography) and artificial intelligence-based data analysis could help to tackle these challenges. These new imaging approaches offer detailed anatomical delineation and an in vivo and non-invasive evaluation of the immunometabolic status of inflammatory reactions, thereby facilitating an in-depth characterization of inflammation. By means of these developments, the aim of earlier diagnosis, enhanced monitoring and, ultimately, a personalized treatment strategy looms closer.

Authors with CRIS profile

Ioanna Minopoulou Department of Medicine 3 – Rheumatology and Immunology Arnd Kleyer Department of Medicine 3 – Rheumatology and Immunology Filippo Fagni Department of Medicine 3 – Rheumatology and Immunology Stephan Kemenes Medizinische Fakultät Christian Schmidkonz Medizinische Fakultät Armin Atzinger Department of Nuclear Medicine Milena Pachowsky Department of Medicine 3 – Rheumatology and Immunology Lukas Folle Lehrstuhl für Informatik 5 (Mustererkennung) Frank Roemer Institute of Radiology Maximilian Waldner Professur für Funktionelle Bildgebung in der Medizin Georg Schett Lehrstuhl für Innere Medizin III David Simon Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Fondazione Policlinico Universitario Agostino Gemelli IRCCS IT Italy (IT)

How to cite

APA:

Minopoulou, I., Kleyer, A., Yalcin-Mutlu, M., Fagni, F., Kemenes, S., Schmidkonz, C.,... Simon, D. (2023). Imaging in inflammatory arthritis: progress towards precision medicine. Nature Reviews Rheumatology, 19(10), 650-665. https://doi.org/10.1038/s41584-023-01016-1

MLA:

Minopoulou, Ioanna, et al. "Imaging in inflammatory arthritis: progress towards precision medicine." Nature Reviews Rheumatology 19.10 (2023): 650-665.

BibTeX: Download