Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations
Sanvido O, Basketter DA, Berthet A, Bloch D, Ezendam J, Hopf NB, Kleinstreuer N, Merolla LL, Uter W, Wiemann C, Wilks MF (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 144
Article Number: 105493
DOI: 10.1016/j.yrtph.2023.105493
Abstract
Like many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause skin sensitisation. Currently, there is little evidence they do, but that could just reflect lack of clinical investigation. Consequently, it is necessary to carry out a safety evaluation process, quantifying risks so that they can be properly managed. A workshop on this topic in 2022 discussed how best to undertake quantitative risk assessment (QRA) for pesticide products, including learning from the experience of industries, notably cosmetics, that already undertake such a process routinely. It also addressed ways to remedy the matter of clinical investigation, even if only to demonstrate the absence of a problem. Workshop participants concluded that QRA for skin sensitisers in pesticide formulations was possible, but required careful justification of any safety factors applied, as well as improvements to the estimation of skin exposure. The need for regulations to stay abreast of the science was also noted. Ultimately, the success of any risk assessment/management for skin sensitisers must be judged by the clinical picture. Accordingly, the workshop participants encouraged the development of more active skin health monitoring amongst groups most exposed to the products.
Authors with CRIS profile
Involved external institutions
State Secretariat for Economic Affairs (SECO)
Switzerland (CH)
Dabmeb Consultancy Ltd
United Kingdom (GB)
Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV)
Switzerland (CH)
Bundesinstitut für Risikobewertung (BfR)
Germany (DE)
Netherlands National Institute for Public Health and the Environment / Rijksinstituut voor Volksgezondheid en Milieu (RIVM)
Netherlands (NL)
National Institute of Environmental Health Sciences (NIEHS)
United States (USA) (US)
Syngenta
United Kingdom (GB)
BASF Österreich GmbH
Austria (AT)
Universität Basel
Switzerland (CH)
Switzerland (CH)
Dabmeb Consultancy Ltd
United Kingdom (GB)
Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV)
Switzerland (CH)
Bundesinstitut für Risikobewertung (BfR)
Germany (DE)
Netherlands National Institute for Public Health and the Environment / Rijksinstituut voor Volksgezondheid en Milieu (RIVM)
Netherlands (NL)
National Institute of Environmental Health Sciences (NIEHS)
United States (USA) (US)
Syngenta
United Kingdom (GB)
BASF Österreich GmbH
Austria (AT)
Universität Basel
Switzerland (CH)
How to cite
APA:
Sanvido, O., Basketter, D.A., Berthet, A., Bloch, D., Ezendam, J., Hopf, N.B.,... Wilks, M.F. (2023). Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations. Regulatory Toxicology and Pharmacology, 144. https://dx.doi.org/10.1016/j.yrtph.2023.105493
MLA:
Sanvido, Olivier, et al. "Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations." Regulatory Toxicology and Pharmacology 144 (2023).
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