Inhaled nintentanib, pirfenidone and macitentan for pulmonary fibrosis: a laboratory experiment
Zarogoulidis P, Petridis D, Huang H, Bai C, Oikonomou P, Nikolaou C, Matthaios D, Perdikouri EI, Papadopoulos V, Petanidis S, Kosmidis C, Charalampidis C, Hohenforst-Schmidt W, Kougkas N, Sardeli C (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 14
Pages Range: 491-498
Journal Issue: 8
Abstract
Aim: Idiopathic pulmonary fibrosis is a rare disease with few efficient drugs in the market. The consequences of this disease are mainly respiratory failure and pulmonary hypertension. Materials & methods: In our experiment we used the drugs pirfenidone, nintetanib and macitentan. We performed nebulization experiments with three jet nebulizers and three ultrasound nebulizers with different combinations of residual cup designs, and residual cup loadings in order to identify which combination produces droplets of less than 5 μm in mass median aerodynamic diameter. Results: Pirfenidone versus nintetanib had smaller droplet size formation at both inhaled technologies (1.37 < 2.23 and 1.92 < 3.11, jet and ultrasound respectively). Discussion: Pirfenidone and nintetanib can be administered as aerosol in any type of nebulization system.
Involved external institutions
Euromedica Geniki Kliniki of Thessaloniki
Greece (GR)
Alexander Technological Educational Institute of Thessaloniki (ATEITH)
Greece (GR)
Changhai Hospital of Shanghai
China (CN)
Democritus University of Thrace (DUTH) / Δημοκρίτειο Πανεπιστήμιο Θράκης
Greece (GR)
General Hospital of Rhodes / Hospital Geniko Nosokomio Rodou "Andreas Papandreou" / Γενικό Νοσοκομείο Ρόδου
Greece (GR)
General Hospital of Volos
Greece (GR)
General University Hospital of Larissa
Greece (GR)
Aristotle University of Thessaloniki
Greece (GR)
AHEPA University General Hospital / Πανεπιστημιακό Νοσοκομείο ΑΧΕΠΑ
Greece (GR)
University of Cyprus (UCY) / Πανεπιστήμιο Κύπρου
Cyprus (CY)
Ippokrateio General Hospital / Γενικό Νοσοκομείο Θεσσαλονίκης "ΙΠΠΟΚΡΑΤΕΙΟ"
Greece (GR)
Sana Kliniken AG
Germany (DE)
Greece (GR)
Alexander Technological Educational Institute of Thessaloniki (ATEITH)
Greece (GR)
Changhai Hospital of Shanghai
China (CN)
Democritus University of Thrace (DUTH) / Δημοκρίτειο Πανεπιστήμιο Θράκης
Greece (GR)
General Hospital of Rhodes / Hospital Geniko Nosokomio Rodou "Andreas Papandreou" / Γενικό Νοσοκομείο Ρόδου
Greece (GR)
General Hospital of Volos
Greece (GR)
General University Hospital of Larissa
Greece (GR)
Aristotle University of Thessaloniki
Greece (GR)
AHEPA University General Hospital / Πανεπιστημιακό Νοσοκομείο ΑΧΕΠΑ
Greece (GR)
University of Cyprus (UCY) / Πανεπιστήμιο Κύπρου
Cyprus (CY)
Ippokrateio General Hospital / Γενικό Νοσοκομείο Θεσσαλονίκης "ΙΠΠΟΚΡΑΤΕΙΟ"
Greece (GR)
Sana Kliniken AG
Germany (DE)
How to cite
APA:
Zarogoulidis, P., Petridis, D., Huang, H., Bai, C., Oikonomou, P., Nikolaou, C.,... Sardeli, C. (2023). Inhaled nintentanib, pirfenidone and macitentan for pulmonary fibrosis: a laboratory experiment. Therapeutic Delivery, 14(8), 491-498. https://doi.org/10.4155/tde-2023-0045
MLA:
Zarogoulidis, Paul, et al. "Inhaled nintentanib, pirfenidone and macitentan for pulmonary fibrosis: a laboratory experiment." Therapeutic Delivery 14.8 (2023): 491-498.
BibTeX: Download