Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study
Formiga F, Badía-Tejero AM, Corsonello A, Ärnlöv J, Carlsson AC, Mattace-Raso F, Tap L, Kostka T, Guligowska A, Sieber C, Kob R, Ben-Romano R, Yehoshua I, Roller-Wirnsberger R, Wirnsberger GH, Fabbietti P, Lattanzio F, Moreno-González R (2023)
Publication Language: English
Publication Type: Journal article, Original article
Publication year: 2023
Journal
Book Volume: 35
Pages Range: 2693-2701
DOI: 10.1007/s40520-023-02536-2
Abstract
Background: Type 2 diabetes mellitus (DM) in older people is a heterogeneous condition that exhibits differential characteristics in comparison with younger adults. DM increases the risk of disability, is associated with dementia and loss of function, and cognition may often be interrelated and more pronounced in older patients with DM than in those without. Aims: Our aim was to evaluate the incidence of functional and/or cognitive impairment in older adults with and without DM, and its associated factors in DM participants. Methods: A 2-year prospective analysis was conducted in a European multicenter prospective cohort (SCOPE study). Older community-dwelling adults (aged ≥ 75 years) underwent a comprehensive geriatric assessment. New functional and/or cognitive decline was explored. Results: Of 1611 participants, 335 (22.0%) had DM at baseline. The percentage of participants scoring at least one ADL impairment and/or cognitive impairment (MMSE < 24) was similar in both groups (9.6%). Factors associated with any new disability in participants with DM in the multivariate analysis were female sex (OR 3.28, 95% CI 1.42–7.56), history of stroke (OR 4.58, 95% CI 1.64–12.7), and greater IADL dependency (OR 1.08 95% CI 1.02–1.15). Discussion: Association between DM and cognitive or functional decline in outpatients of 75 years and older was not found, but factors such as female gender, history of stroke, and IADL dependency could be related. Conclusion: Decline in functional and cognitive status of community-dwelling older adults with DM was similar to participants without DM in a short period of 2 years of follow-up, though several clinical factors may increase its risk in this population.
Authors with CRIS profile
Cornel Sieber
Lehrstuhl für Innere Medizin (Geriatrie)
Robert Kob
Lehrstuhl für Innere Medizin (Geriatrie)
Involved external institutions
Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב
Israel (IL)
Erasmus University Medical Center (MC)
Netherlands (NL)
Medical University of Łódź / Uniwersytet Medyczny w Łodzi
Poland (PL)
Bellvitge University Hospital / Hospital Universitari de Bellvitge
Spain (ES)
Karolinska Institute
Sweden (SE)
Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA)
Italy (IT)
Medizinische Universität Graz
Austria (AT)
Università della Calabria (UNICAL)
Italy (IT)
Israel (IL)
Erasmus University Medical Center (MC)
Netherlands (NL)
Medical University of Łódź / Uniwersytet Medyczny w Łodzi
Poland (PL)
Bellvitge University Hospital / Hospital Universitari de Bellvitge
Spain (ES)
Karolinska Institute
Sweden (SE)
Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA)
Italy (IT)
Medizinische Universität Graz
Austria (AT)
Università della Calabria (UNICAL)
Italy (IT)
How to cite
APA:
Formiga, F., Badía-Tejero, A.M., Corsonello, A., Ärnlöv, J., Carlsson, A.C., Mattace-Raso, F.,... Moreno-González, R. (2023). Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study. Aging Clinical and Experimental Research, 35, 2693-2701. https://doi.org/10.1007/s40520-023-02536-2
MLA:
Formiga, Francesc, et al. "Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study." Aging Clinical and Experimental Research 35 (2023): 2693-2701.
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