FET-PET for malignant glioma treatment planning

Niyazi M, Geisler J, Siefert A, Schwarz SB, Ganswindt U, Garny S, Schnell O, Suchorska B, Kreth FW, Tonn JC, Bartenstein P, Fougre CL, Belka C (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Radiotherapy and Oncology Elsevier

Book Volume: 99

Pages Range: 44-48

Journal Issue: 1

DOI: 10.1016/j.radonc.2011.03.001

Abstract

Background and purpose: The aim of this study was to compare MRI-based morphological gross tumour volumes (GTVs) to biological tumour volumes (BTVs), defined by the pathological radiotracer uptake in positron emission tomography (PET) imaging with 18F-fluoroethyltyrosine (FET), subsequently clinical target volumes (CTVs) and finally planning target volumes (PTVs) for radiotherapy planning of glioblastoma. Patients and methods: Seventeen patients with glioblastoma were included into a retrospective protocol. Treatment-planning was performed using clinical target volume (CTV = BTV + 20 mm or CTV = GTV + 20 mm + inclusion of the edema) and planning target volume (PTV = CTV + 5 mm). Image fusion and target volume delineation were performed with OTP-Masterplan®. Initial gross tumour volume (GTV) definition was based on MRI data only or FET-PET data only (BTV), secondarily both data sets were used to define a common CTV. Results: FET based BTVs (median 43.9 cm3) were larger than corresponding GTVs (median 34.1 cm3, p = 0.028), in 11 of 17 cases there were major differences between GTV/BTV. To evaluate the conformity of both planning methods, the index (CTVMRT ∩ CTV FET)/(CTVMRT ∪ CTVFET) was quantified which was significantly different from 1 (0.73 ± 0.03, p < 0.001). Conclusion: With FET-PET-CT planning, the size and geometrical location of GTVs/BTVs differed in a majority of patients. It remains open whether FET-PET-based target definition has a relevant clinical impact for treatment planning. © 2011 Elsevier Ireland Ltd All rights reserved. Radiotherapy and Oncology.

Authors with CRIS profile

Oliver Schnell

Involved external institutions

Ludwig-Maximilians-Universität (LMU) DE Germany (DE)

How to cite

APA:

Niyazi, M., Geisler, J., Siefert, A., Schwarz, S.B., Ganswindt, U., Garny, S.,... Belka, C. (2011). FET-PET for malignant glioma treatment planning. Radiotherapy and Oncology, 99(1), 44-48. https://doi.org/10.1016/j.radonc.2011.03.001

MLA:

Niyazi, Maximilian, et al. "FET-PET for malignant glioma treatment planning." Radiotherapy and Oncology 99.1 (2011): 44-48.

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