Microglia contribute to the propagation of Aβ into unaffected brain tissue

d’Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nature Neuroscience Nature Publishing Group

Book Volume: 25

Pages Range: 20-25

Journal Issue: 1

DOI: 10.1038/s41593-021-00951-0

Abstract

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation.

Authors with CRIS profile

Oliver Schnell

Involved external institutions

Universitätsklinikum Freiburg DE Germany (DE) Albert-Ludwigs-Universität Freiburg DE Germany (DE) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) DE Germany (DE) LMU Klinikum DE Germany (DE)

How to cite

APA:

d’Errico, P., Ziegler-Waldkirch, S., Aires, V., Hoffmann, P., Mezö, C., Erny, D.,... Meyer-Luehmann, M. (2022). Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nature Neuroscience, 25(1), 20-25. https://doi.org/10.1038/s41593-021-00951-0

MLA:

d’Errico, Paolo, et al. "Microglia contribute to the propagation of Aβ into unaffected brain tissue." Nature Neuroscience 25.1 (2022): 20-25.

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