Quality of Life After Poor-Grade Aneurysmal Subarachnoid Hemorrhage
Goldberg J, Z'Graggen WJ, Hlavica M, Branca M, Marbacher S, D'Alonzo D, Fandino J, Stienen MN, Neidert MC, Burkhardt JK, Regli L, Seule M, Roethlisberger M, Guzman R, Zumofen DW, Maduri R, Daniel RT, El Rahal A, Corniola MV, Bijlenga P, Schaller K, Rölz R, Scheiwe C, Shah M, Heiland DH, Schnell O, Beck J, Raabe A (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 92
Pages Range: 1052-1057
Journal Issue: 5
DOI: 10.1227/neu.0000000000002332
Abstract
BACKGROUND: Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) is associated with high mortality and poor disability outcome. Data on quality of life (QoL) among survivors are scarce because patients with poor-grade aSAH are underrepresented in clinical studies reporting on QoL after aSAH. OBJECTIVE: To provide prospective QoL data on survivors of poor-grade aSAH to aid clinical decision making and counseling of relatives. METHODS: The herniation World Federation of Neurosurgical Societies scale study was a prospective observational multicenter study in patients with poor-grade (World Federation of Neurosurgical Societies grades 4 & 5) aSAH. We collected data during a structured telephone interview 6 and 12 months after ictus. QoL was measured using the EuroQoL - 5 Dimensions - 3 Levels (EQ-5D-3L) questionnaire, with 0 representing a health state equivalent to death and 1 to perfect health. Disability outcome for favorable and unfavorable outcomes was measured with the modified Rankin Scale. RESULTS: Two hundred-fifty patients were enrolled, of whom 237 were included in the analysis after 6 months and 223 after 12 months. After 6 months, 118 (49.8%) patients were alive, and after 12 months, 104 (46.6%) patients were alive. Of those, 95 (80.5%) and 89 (85.6%) reached a favorable outcome with mean EQ-5D-3L index values of 0.85 (±0.18) and 0.86 (±0.18). After 6 and 12 months, 23 (19.5%) and 15 (14.4%) of those alive had an unfavorable outcome with mean EQ-5D-3L index values of 0.27 (±0.25) and 0.19 (±0.14). CONCLUSION: Despite high initial mortality, the proportion of poor-grade aSAH survivors with good QoL is reasonably large. Only a minority of survivors reports poor QoL and requires permanent care.
Authors with CRIS profile
Involved external institutions
Inselspital, Universitätsspital Bern
Switzerland (CH)
Universität Bern
Switzerland (CH)
Kantonsspital Aarau AG
Switzerland (CH)
Kantonsspital St.Gallen
Switzerland (CH)
Universitätsspital Zürich (USZ)
Switzerland (CH)
Universitätsspital Basel
Switzerland (CH)
Maimonides Medical Center
United States (USA) (US)
Swiss Medical Network
Switzerland (CH)
Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV)
Switzerland (CH)
Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG)
Switzerland (CH)
Universitätsklinikum Freiburg
Germany (DE)
Switzerland (CH)
Universität Bern
Switzerland (CH)
Kantonsspital Aarau AG
Switzerland (CH)
Kantonsspital St.Gallen
Switzerland (CH)
Universitätsspital Zürich (USZ)
Switzerland (CH)
Universitätsspital Basel
Switzerland (CH)
Maimonides Medical Center
United States (USA) (US)
Swiss Medical Network
Switzerland (CH)
Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV)
Switzerland (CH)
Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG)
Switzerland (CH)
Universitätsklinikum Freiburg
Germany (DE)
How to cite
APA:
Goldberg, J., Z'Graggen, W.J., Hlavica, M., Branca, M., Marbacher, S., D'Alonzo, D.,... Raabe, A. (2023). Quality of Life After Poor-Grade Aneurysmal Subarachnoid Hemorrhage. Neurosurgery, 92(5), 1052-1057. https://dx.doi.org/10.1227/neu.0000000000002332
MLA:
Goldberg, Johannes, et al. "Quality of Life After Poor-Grade Aneurysmal Subarachnoid Hemorrhage." Neurosurgery 92.5 (2023): 1052-1057.
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