Unseld LH, Hildebrand L, Putz F, Büttner-Herold M, Daniel C, Fietkau R, Distel L (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 30
Pages Range: 7542-7552
Journal Issue: 8
DOI: 10.3390/curroncol30080547
Non-professional phagocytosis in cancer has been increasingly studied in recent decades. In malignant melanoma metastasis, cell-in-cell structures have been described as a sign of cell cannibalism. To date, only low rates of cell-in-cell structures have been described in patients with malignant melanoma. To investigate these findings further, we examined twelve primary melanoma cell lines in both adherent and suspended co-incubation for evidence of engulfment. In addition, 88 malignant melanoma biopsies and 16 healthy tissue samples were evaluated. E-cadherin levels were determined in the cell lines and tissues. All primary melanoma cell lines were capable of phagocytosis, and phagocytosis increased when cells were in suspension during co-incubation. Cell-in-cell structures were also detected in most of the tissue samples. Early T stages and increasingly advanced N and M stages have correspondingly lower rates of cell-in-cell structures. Non-professional phagocytosis was also present in normal skin tissue. Non-professional phagocytosis appears to be a ubiquitous mechanism in malignant melanoma. The absence of phagocytosis in metastases may be one reason for the high rate of metastasis in malignant melanoma.
APA:
Unseld, L.H., Hildebrand, L., Putz, F., Büttner-Herold, M., Daniel, C., Fietkau, R., & Distel, L. (2023). Non-Professional Phagocytosis Increases in Melanoma Cells and Tissues with Increasing E-Cadherin Expression. Current Oncology, 30(8), 7542-7552. https://doi.org/10.3390/curroncol30080547
MLA:
Unseld, Luzie Helene, et al. "Non-Professional Phagocytosis Increases in Melanoma Cells and Tissues with Increasing E-Cadherin Expression." Current Oncology 30.8 (2023): 7542-7552.
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