Predictive value of tumor budding in head and neck squamous cell carcinoma: an update

Chiesa-Estomba CM, Thompson L, Agaimy A, Zidar N, Simpson RH, Franchi A, Rodrigo JP, Mäkitie AA, Almangush A, Leivo I, Ferlito A (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Virchows Archiv Springer Verlag (Germany)

DOI: 10.1007/s00428-023-03630-6

Abstract

Head and neck squamous cell carcinoma forms an anatomically and functionally complex group of malignancies. The significant local aggressiveness and frequent regional relapses motivate ongoing research to identify more reliable and sensitive prognostic and predictive biomarkers. One emerging area of cancer biology is the evaluation of tumor budding at the advancing invasive front of various types of epithelial cancers. Recent studies suggest that tumor budding is a relatively common phenomenon in cancer progression and that it may have important prognostic implications for patients due to its potential to provide valuable insights into the biology and clinical behavior of head and neck cancer. In this review, we aim to provide information about tumor budding in head and neck squamous cell carcinoma. Thus, we hope to shed light on the complex biology of these malignancies, as well as aiding diagnostic, classification, and better characterization and thereby, looking for new avenues for improving patient outcomes.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Donostia University Hospital / Donostia Unibertsitate Ospitalea ES Spain (ES) University of Ljubljana (UL) / Univerza v Ljubljani SI Slovenia (SI) University of Calgary CA Canada (CA) University of Pisa / Università di Pisa (UniPi) IT Italy (IT) Central University Hospital of Asturias ES Spain (ES) Helsinki University Central Hospital (HUCH) / Helsingin seudun yliopistollinen keskussairaala (HYKS) FI Finland (FI) University of Turku / Turun yliopisto FI Finland (FI) Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS) FI Finland (FI) International Head and Neck Scientific Group DE Germany (DE)

How to cite

APA:

Chiesa-Estomba, C.M., Thompson, L., Agaimy, A., Zidar, N., Simpson, R.H., Franchi, A.,... Ferlito, A. (2023). Predictive value of tumor budding in head and neck squamous cell carcinoma: an update. Virchows Archiv. https://doi.org/10.1007/s00428-023-03630-6

MLA:

Chiesa-Estomba, Carlos M., et al. "Predictive value of tumor budding in head and neck squamous cell carcinoma: an update." Virchows Archiv (2023).

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