Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability

Xu Z, Keller E, Beltrán AM, Zheng K, Boccaccini AR (2023)


Publication Type: Journal article

Publication year: 2023

Journal

Book Volume: 620

Article Number: 122578

DOI: 10.1016/j.jnoncrysol.2023.122578

Abstract

Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible post-impregnation approach to incorporate metallic ions (Ca and Ce) into dendritic mesoporous silica nanoparticles, resulting in SiO2-CaO and SiO2-CaO-CeO2 (Ce-DMBGNs) without destroying the dendritic mesoporous topography. Both DMBGNs and Ce-DMBGNs were amorphous, negatively charged, with a hydrodynamic size of ∼200 nm. The synthesized DMBGNs and Ce-DMBGNs exhibited high bioactivity as evidenced by the rapid formation of hydroxyapatite (HA) after immersion in simulated body fluid (SBF) for 7 days. In addition, DMBGNs and Ce-DMBGNs showed high propolis loading efficiency and sustained release behavior. The results suggest that the developed Ce-DMBGNs have the potential to be used as a delivery vehicle of therapeutic ions and drugs in bone regeneration applications.

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How to cite

APA:

Xu, Z., Keller, E., Beltrán, A.M., Zheng, K., & Boccaccini, A.R. (2023). Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability. Journal of Non-Crystalline Solids, 620. https://doi.org/10.1016/j.jnoncrysol.2023.122578

MLA:

Xu, Zhiyan, et al. "Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability." Journal of Non-Crystalline Solids 620 (2023).

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