Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Ely S, Fernandez-Martín C, Fineberg S, Fox SB, Gallagher WM, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hardas A, Hart SN, Hartman J, Hewitt S, Hida AI, Horlings HM, Husain Z, Hytopoulos E, Irshad S, Janssen EA, Kahila M, Kataoka TR, Kawaguchi K, Kharidehal D, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Ly A, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Minhas FuAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rahman A, Rajpoot NM, Rapoport BL, Rau TT, Reis-Filho JS, Ribeiro JM, Rimm D, Salomon AV, Salto-Tellez M, Saltz J, Sayed S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, van Diest PJ, Verghese GE, Viale G, Vieth M, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Adams S, Bartlett JMS, Loibl S, Denkert C, Savas P, Loi S, Salgado R, Specht Stovgaard E, Akturk G, Bouchmaa N (2023)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Book Volume: 260

Pages Range: 514-532

Journal Issue: 5

DOI: 10.1002/path.6165

Abstract

Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland.

Authors with CRIS profile

Involved external institutions

Karolinska Institute Sweden (SE) Fudan University / 复旦大学 China (CN) New York University (NYU) United States (USA) (US) Hospital María Curie Argentina (AR) State University of New York at Albany (UNY Albany / UAlbany) United States (USA) (US) The National University of Malaysia / Universiti Kebangsaan Malaysia (UKM) Malaysia (MY) Yale University United States (USA) (US) CRUK Lung Cancer Centre of Excellence United Kingdom (GB) University of Birmingham United Kingdom (GB) Centro Medico Nacional Siglo XXI Mexico (MX) Northwestern University United States (USA) (US) University of Pennsylvania (UPenn) United States (USA) (US) Medical Oncology Centre of Rosebank South Africa (ZA) Aga Khan University (AKU) / آغا خان یونیورسٹی‎ Pakistan (PK) Institut Jules Bordet Belgium (BE) Kyoto University / 京都大学 Kyōto daigaku Japan (JP) Aarhus University Hospital / Aarhus Universitetshospital Denmark (DK) King’s College London United Kingdom (GB) Memorial Sloan Kettering Cancer Center United States (USA) (US) GBG Forschungs GmbH (German Breast Group) Germany (DE) Icahn School of Medicine at Mount Sinai United States (USA) (US) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Case Western Reserve University United States (USA) (US) Mayo Clinic United States (USA) (US) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Narayana Medical College & Hospital India (IN) Institut Gustave-Roussy France (FR) King Hussein Cancer Center (KHCC) / مركز الحسين للسرطان Jordan (JO) University of Texas MD Anderson Cancer Center United States (USA) (US) The Institute of Cancer Research (ICR) United Kingdom (GB) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) University of Edinburgh United Kingdom (GB) Merck & Co., Inc. / Merck Sharp & Dohme Corp (MSD) United States (USA) (US) Hospital Universitário Getúlio Vargas (HUGV) Brazil (BR) GZA Ziekenhuizen Belgium (BE) Weill Cornell Medicine United States (USA) (US) Philipps-Universität Marburg Germany (DE) Ziauddin University (ZU) Pakistan (PK) The University of Melbourne Australia (AU) Genentech Inc. United States (USA) (US) Bristol-Myers Squibb United States (USA) (US) Polytechnic University of Valencia / Universidad Politécnica de Valencia Spain (ES) Albert Einstein College of Medicine United States (USA) (US) University College Dublin (UCD) Ireland (IE) University of London United Kingdom (GB) National Cancer Institute (NCI) United States (USA) (US) Matsuyama Shimin Hospital / 松山市民病院 Japan (JP) Praava Health Bangladesh (BD) Allergan Pharmaceuticals, Inc. United States (USA) (US) Iwate Medical University Japan (JP) Aakash Healthcare Super Speciality Hospital India (IN) Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI / NKI-AVL) Netherlands (NL) F. Hoffmann-La Roche Ltd Switzerland (CH) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset Sweden (SE) Emory University United States (USA) (US) Massachusetts General Hospital United States (USA) (US) Stony Brook Medicine United States (USA) (US) Universitätsklinikum Heidelberg Germany (DE) Iuliu Hațieganu University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Iuliu Hațieganu" (UMF Cluj) Romania (RO) Peter MacCallum Cancer Centre Australia (AU) Sunnybrook Health Sciences Centre Canada (CA) University Medical Centre Utrecht (UMC Utrecht) Netherlands (NL) European Institute of Oncology / Istituto Europeo di Oncologia (IEO) Italy (IT) University of Warwick United Kingdom (GB) Mines ParisTech / École Nationale Supérieure des Mines de Paris (ENSMP) France (FR) CellCarta Canada (CA) Copenhagen University Hospital Denmark (DK) Université Mohammed VI Polytechnique (UM6P) Morocco (MA) Heinrich-Heine-Universität Düsseldorf Germany (DE) Institut Curie France (FR) Tempus Labs United States (USA) (US) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) Mayo Clinic Hospital United States (USA) (US) Fondazione IRCCS: Istituto Nazionale dei Tumori Italy (IT) Earle A. Chiles Research Institute at the Robert W. Franz Cancer Center United States (USA) (US) University College Hospital United Kingdom (GB) University of British Columbia Canada (CA) University of the Frontier / Universidad de La Frontera (UFRO) Chile (CL) Federal University of Amazonas / Universidade Federal do Amazonas (UFAM) Brazil (BR) University of Surrey United Kingdom (GB) Vanderbilt University United States (USA) (US) Stavanger University Hospital Norway (NO) Manipal Hospitals India India (IN) University of Washington United States (USA) (US) All India Institute of Medical Sciences Raipur (AIIMS) / अखिल भारतीय आयुर्विज्ञान संस्थान रायपुर India (IN) Centre Jean-Perrin (UNICANCER) France (FR) Tehran University of Medical Sciences (TUMS) / دانشگاه علوم پزشکی تهران Iran, Islamic Republic of (IR) Hospital Clínico Universitario de Valencia Spain (ES) Georgia Institute of Technology United States (USA) (US) National Surgical Adjuvant Breast and Bowel Project Foundation (NSABP) United States (USA) (US) ICGA Foundation India (IN) Technical University of Denmark / Danmarks Tekniske Universitet (DTU) Denmark (DK) Guy's and St Thomas' (NHS Foundation Trust) United Kingdom (GB) Ann & Robert H. Lurie Children's Hospital of Chicago United States (USA) (US) Sjællands Universitetshospital, Roskilde Denmark (DK)

How to cite

APA:

Page, D.B., Broeckx, G., Jahangir, C.A., Verbandt, S., Gupta, R.R., Thagaard, J.,... Bouchmaa, N. (2023). Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 260(5), 514-532. https://doi.org/10.1002/path.6165

MLA:

Page, David B., et al. "Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 260.5 (2023): 514-532.

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