Düll M, Namer B (2023)
Publication Type: Authored book
Publication year: 2023
Publisher: Nova Science Publisher Inc.
ISBN: 9798886978827
Microneurography (MNG) represents the only method for recording activity of single peripheral nerve fibers in awake human subjects. It objectively allows for a correlation between nerve fiber activity and subjective sensations such as itch and pain. While recent results from molecular biology and animal studies have provided great insights into the mechanisms and molecules involved in itch signaling, we still have to consider species differences and the translation to human patient conditions. Overall, this calls for aiming at more translational studies to close the gap between new findings in basic science and clinically relevant problems. MNG is an optimal tool to further examine C-nerve fibers in this context. The MNG technique contributed to the identification of histamine-sensitive mechano-insensitive C-fibers (CMi His+), which mediate the peripheral input of histaminergic itch in human. In most clinical conditions, non-histaminergic itch signaling seems to play a more important role, and contributing mechanisms are still not fully understood. MNG recordings revealed that mechano-sensitive C-fibers (CM) mediate cowhage-dependent itch as an example of nonhistaminergic itch. Recently, MNG results also contributed to the idea that different activation mechanisms are necessary for the induction of non-histaminergic itch, such as spatial contrast, population and pattern coding.
APA:
Düll, M., & Namer, B. (2023). Microneurography for assessing mechanisms of itch signaling in humans. Nova Science Publisher Inc..
MLA:
Düll, Miriam, and Barbara Namer. Microneurography for assessing mechanisms of itch signaling in humans. Nova Science Publisher Inc., 2023.
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