The beer component hordenine inhibits alcohol addiction-associated behaviours in mice

Li Y, Vogel C, Kalinichenko L, Hübner H, Weikert D, Schaefer N, Gmeiner P, Villmann C, Pischetsrieder M, Müller CP (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Addiction Biology Wiley-Blackwell

Book Volume: 28

Article Number: e13305

Journal Issue: 8

DOI: 10.1111/adb.13305

Abstract

Alcohol consumption is a widespread behaviour that may eventually result in the development of alcohol use disorder (AUD). Alcohol, however, is rarely consumed in pure form but in fruit- or corn-derived preparations, like beer. These preparations add other compounds to the consumption, which may critically modify alcohol intake and AUD risk. We investigated the effects of hordenine, a barley-derived beer compound on alcohol use-related behaviours. We found that the dopamine D2 receptor agonist hordenine (50 mg/kg) limited ongoing alcohol consumption and prophylactically diminished relapse drinking after withdrawal in mice. Although not having reinforcing effects on its own, hordenine blocked the establishment of alcohol-induced conditioned place preference (CPP). However, it independently enhanced alcohol CPP retrieval. Hordenine had a dose-dependent inhibitory effect on locomotor activity. Chronic hordenine exposure enhanced monoamine tissue levels in many brain regions. Further characterization revealed monoaminergic binding sites of hordenine and found a strong binding on the serotonin and dopamine transporters, and dopamine D3, and adrenergic α1A and α2A receptor activation but no effects on GABAA receptor or glycinergic signalling. These findings suggest that natural ingredients of beer, like hordenine, may work as an inhibitory and use-regulating factor by their modulation of monoaminergic signalling in the brain.

Authors with CRIS profile

Yan Li Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Liubov Kalinichenko Department of Psychiatry and Psychotherapy Harald Hübner Lehrstuhl für Pharmazeutische Chemie Dorothée Weikert Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie Monika Pischetsrieder Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Peter Christian Müller Professur für Suchtmedizin

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Li, Y., Vogel, C., Kalinichenko, L., Hübner, H., Weikert, D., Schaefer, N.,... Müller, C.P. (2023). The beer component hordenine inhibits alcohol addiction-associated behaviours in mice. Addiction Biology, 28(8). https://doi.org/10.1111/adb.13305

MLA:

Li, Yan, et al. "The beer component hordenine inhibits alcohol addiction-associated behaviours in mice." Addiction Biology 28.8 (2023).

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