Dregelies T, Haumaier F, Sterlacci W, Backert S, Vieth M (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 80
Article Number: 293
Journal Issue: 9
DOI: 10.1007/s00284-023-03398-7
Fusobacterium nucleatum is supposed to play a critical role in the development of colorectal cancer. The species has also been associated with ulcerative colitis (UC) that can progress into colorectal cancer, however, the involvement of bacteria in this process remains unclear. We analysed 177 colon biopsies obtained from patients during screening, including 20 healthy controls, 56 UC cases and 69 cases at different stages of progression to colitis-associated cancer (CAC); 32 samples of sporadic colorectal carcinoma (sCRC) were also included. The presence of F. nucleatum was detected by quantitative real-time PCR (qPCR). Our data show an association between the presence of the bacteria and the progression of carcinogenesis in UC patients. In 39.5% of CAC samples F. nucleatum was detected, compared to only 1.8% in UC cases. The bacteria were detected in 6.3% of samples with initial neoplastic transformation, so-called low-grade dysplasia (LGD), whereas high-grade dysplasia (HGD) resulted in 33.3% of samples positive for F. nucleatum. The fraction of F. nucleatum-positive samples from sCRC cases was 56.3%, which was not significantly different to the CAC group. We conclude that F. nucleatum is associated with the occurrence and progression of colon carcinogenesis, rather than with UC itself.
APA:
Dregelies, T., Haumaier, F., Sterlacci, W., Backert, S., & Vieth, M. (2023). Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer. Current Microbiology, 80(9). https://doi.org/10.1007/s00284-023-03398-7
MLA:
Dregelies, Theresa, et al. "Detection of Fusobacterium nucleatum in Patients with Colitis-Associated Colorectal Cancer." Current Microbiology 80.9 (2023).
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