Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds

Dogrul F, Bednarzig V, Elsayed H, Liverani L, Galusek D, Bernardo E, Boccaccini AR (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Open Ceramics Elsevier

Book Volume: 15

Article Number: 100413

DOI: 10.1016/j.oceram.2023.100413

Abstract

Reticulated åkermanite (Ca2MgSi2O7) 3D scaffolds were fabricated by direct ink writing of pastes based on a commercial silicone resin and fillers, such as calcium carbonate (CaCO3) and magnesium hydroxide (Mg(OH)2) microparticles, followed by heat treatment at 1100 °C in air. To form liquid phase upon firing and thus promote the ionic interdiffusion, borax (Na2B4O7·10H2O) or hydrated sodium phosphate (Na2HPO4·12H2O) were considered as alternative additives. Although leading to scaffolds with different strength-to-density ratio, the two additives did not lead to substantial differences in terms of biological response. All fabricated ceramics exhibited acellular in-vitro bioactivity upon immersion in simulated-body-fluid (SBF) as well as antibacterial activity against S. aureus and E. coli. Direct contact cell viability test, performed with a stromal-cell line from mouse bone marrow (ST-2 cells), indicated no cytotoxicity of both samples determined by the WST-8 assay.

Authors with CRIS profile

Vera Bednarzig Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Trenčianska univerzita Alexandra Dubčeka v Trenčíne

Slovakia (SK) University of Padua / Universita degli Studi di Padova

Italy (IT)

How to cite

APA:

Dogrul, F., Bednarzig, V., Elsayed, H., Liverani, L., Galusek, D., Bernardo, E., & Boccaccini, A.R. (2023). Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds. Open Ceramics, 15. https://doi.org/10.1016/j.oceram.2023.100413

MLA:

Dogrul, Fulden, et al. "Assessment of in-vitro bioactivity, biodegradability and antibacterial activity of polymer-derived 3D printed åkermanite scaffolds." Open Ceramics 15 (2023).

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