Snapshot CEST++: Advancing rapid whole-brain APTw-CEST MRI at 3 T

Sedykh M, Liebig P, Herz K, Fabian M, Mennecke A, Weinmüller S, Schmidt M, Dörfler A, Zaiß M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Abstract

APTw CEST MRI suffers from long preparation times and consequently long acquisition times (~5 min). Recently, a consensus on the preparation module for clinical APTw CEST at 3 T was found in the community, and we present a fast whole-brain APTw CEST MRI sequence following this consensus preparation of pulsed RF irradiation of 2 s duration at 90% RF duty-cycle and a B1,rms of 2 μT. After optimization of the snapshot CEST approach for APTw imaging regarding flip angle, voxel size and frequency offset sampling, we extend it by undersampled GRE acquisition and compressed sensing reconstruction. This allows 2 mm isotropic whole-brain APTw imaging for clinical research at 3 T below 2 min. With this sequence, a fast snapshot APTw imaging method is now available for larger clinical studies of brain tumors.

Authors with CRIS profile

Maria Sedykh Neuroradiologisches Institut Moritz Fabian Department of Neuroradiology Angelika Mennecke Department of Neuroradiology Simon Weinmüller Department of Neuroradiology Manuel Schmidt Department of Neuroradiology Arnd Dörfler Department of Neuroradiology Moritz Zaiß Professur für Multimodale Bildgebung in der klinischen Forschung

Involved external institutions

Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics

Germany (DE)

How to cite

APA:

Sedykh, M., Liebig, P., Herz, K., Fabian, M., Mennecke, A., Weinmüller, S.,... Zaiß, M. (2023). Snapshot CEST++: Advancing rapid whole-brain APTw-CEST MRI at 3 T. NMR in Biomedicine. https://doi.org/10.1002/nbm.4955

MLA:

Sedykh, Maria, et al. "Snapshot CEST++: Advancing rapid whole-brain APTw-CEST MRI at 3 T." NMR in Biomedicine (2023).

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