Semi-Automated Recording of Facial Sensitivity in Rat Demonstrates Antinociceptive Effects of the Anti-CGRP Antibody Fremanezumab

Benedicter N, Meßlinger K, Vogler B, Mackenzie KD, Stratton J, Friedrich N, Dux M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Neurology International PAGEpress / PAGEPress Publications

Book Volume: 15

Pages Range: 622-637

Journal Issue: 2

DOI: 10.3390/neurolint15020039

Abstract

Migraine pain is frequently accompanied by cranial hyperalgesia and allodynia. Calcitonin gene-related peptide (CGRP) is implicated in migraine pathophysiology but its role in facial hypersensitivity is not entirely clear. In this study, we investigated if the anti-CGRP monoclonal antibody fremanezumab, which is therapeutically used in chronic and episodic migraines, can modify facial sensitivity recorded by a semi-automatic system. Rats of both sexes primed to drink from a sweet source had to pass a noxious mechanical or heat barrier to reach the source. Under these experimental conditions, animals of all groups tended to drink longer and more when they had received a subcutaneous injection of 30 mg/kg fremanezumab compared to control animals injected with an isotype control antibody 12–13 days prior to testing, but this was significant only for females. In conclusion, anti-CGRP antibody, fremanezumab, reduces facial sensitivity to noxious mechanical and thermal stimulation for more than one week, especially in female rats. Anti-CGRP antibodies may reduce not only headache but also cranial sensitivity in migraineurs.

Authors with CRIS profile

Nicola Benedicter Medizinische Fakultät Karl Meßlinger Professur für Zelluläre und Molekulare Neurophysiologie Birgit Vogler Lehrstuhl für Physiologie

Involved external institutions

Teva Pharmaceutical Industries Ltd. IL Israel (IL) University of Szeged / József Attila Tudományegyetem Szeged HU Hungary (HU)

How to cite

APA:

Benedicter, N., Meßlinger, K., Vogler, B., Mackenzie, K.D., Stratton, J., Friedrich, N., & Dux, M. (2023). Semi-Automated Recording of Facial Sensitivity in Rat Demonstrates Antinociceptive Effects of the Anti-CGRP Antibody Fremanezumab. Neurology International, 15(2), 622-637. https://doi.org/10.3390/neurolint15020039

MLA:

Benedicter, Nicola, et al. "Semi-Automated Recording of Facial Sensitivity in Rat Demonstrates Antinociceptive Effects of the Anti-CGRP Antibody Fremanezumab." Neurology International 15.2 (2023): 622-637.

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