3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering

Polley C, Distler T, Scheufler C, Detsch R, Lund H, Springer A, Schneidereit D, Friedrich O, Boccaccini AR, Seitz H (2023)

Publication Type: Journal article, Original article

Publication year: 2023

Journal

Book Volume: 21

Article Number: 100719

DOI: 10.1016/j.mtbio.2023.100719

Abstract

Bone healing is a complex process orchestrated by various factors, such as mechanical, chemical and electrical cues. Creating synthetic biomaterials that combine several of these factors leading to tailored and controlled tissue regeneration, is the goal of scientists worldwide. Among those factors is piezoelectricity which creates a physiological electrical microenvironment that plays an important role in stimulating bone cells and fostering bone regeneration. However, only a limited number of studies have addressed the potential of combining piezoelectric biomaterials with state-of-the-art fabrication methods to fabricate tailored scaffolds for bone tissue engineering. Here, we present an approach that takes advantage of modern additive manufacturing techniques to create macroporous biomaterial scaffolds based on a piezoelectric and bioactive ceramic-crystallised glass composite. Using binder jetting, scaffolds made of barium titanate and 45S5 bioactive glass are fabricated and extensively characterised with respect to their physical and functional properties. The 3D-printed ceramic-crystallised glass composite scaffolds show both suitable mechanical strength and bioactive behaviour, as represented by the accumulation of bone-like calcium phosphate on the surface. Piezoelectric scaffolds that mimic or even surpass bone with piezoelectric constants ranging from 1 to 21 pC/N are achieved, depending on the composition of the composite. Using MC3T3-E1 osteoblast precursor cells, the scaffolds show high cytocompatibility coupled with cell attachment and proliferation, rendering the barium titanate/45S5 ceramic-crystallised glass composites promising candidates for bone tissue engineering.

Authors with CRIS profile

Involved external institutions

Universität Rostock Germany (DE) Leibniz-Institut für Katalyse (LIKAT) / Leibniz Institute for Catalysis Germany (DE) Universitätsmedizin Rostock Germany (DE)

How to cite

APA:

Polley, C., Distler, T., Scheufler, C., Detsch, R., Lund, H., Springer, A.,... Seitz, H. (2023). 3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering. Materials Today Bio, 21. https://dx.doi.org/10.1016/j.mtbio.2023.100719

MLA:

Polley, Christian, et al. "3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering." Materials Today Bio 21 (2023).

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