Nüse B, Holland T, Rauh M, Gerlach R, Mattner J (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Book Volume: 15
Article Number: 2222961
Journal Issue: 1
DOI: 10.1080/19490976.2023.2222961
L-arginine (L-arg) is a versatile amino acid and a central intestinal metabolite in mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple metabolic pathways in the regulation of cell division and growth. It also serves as a source of carbon, nitrogen, and energy or as a substrate for protein synthesis. Consequently, L-arg can simultaneously modify mammalian immune functions, intraluminal metabolism, intestinal microbiota, and microbial pathogenesis. While dietary intake, protein turnover or de novo synthesis usually supply L-arg in sufficient amounts, the expression of several key enzymes of L-arg metabolism can change rapidly and dramatically following inflammation, sepsis, or injury. Consequently, the availability of L-arg can be restricted due to increased catabolism, transforming L-arg into an essential amino acid. Here, we review the enzymatic pathways of L-arg metabolism in microbial and mammalian cells and their role in immune function, intraluminal metabolism, colonization resistance, and microbial pathogenesis in the gut.
APA:
Nüse, B., Holland, T., Rauh, M., Gerlach, R., & Mattner, J. (2023). L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut. Gut Microbes, 15(1). https://doi.org/10.1080/19490976.2023.2222961
MLA:
Nüse, Björn, et al. "L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut." Gut Microbes 15.1 (2023).
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