The bone marrow side of axial spondyloarthritis

Mauro D, Gandolfo S, Tirri E, Schett G, Maksymowych WP, Ciccia F (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Nature Reviews Rheumatology Nature Publishing Group

DOI: 10.1038/s41584-023-00986-6

Abstract

Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune cells into entheses and bone marrow. Molecular, cellular and imaging evidence demonstrates the presence of bone marrow inflammation, a hallmark of SpA. In the spine and the peripheral joints, bone marrow is critically involved in the pathogenesis of SpA. Evidence suggests that bone marrow inflammation is associated with enthesitis and that there are roles for mechano-inflammation and intestinal inflammation in bone marrow involvement in SpA. Specific cell types (including mesenchymal stem cells, innate lymphoid cells and γδ T cells) and mediators (Toll-like receptors and cytokines such as TNF, IL-17A, IL-22, IL-23, GM-CSF and TGFβ) are involved in these processes. Using this evidence to demonstrate a bone marrow rather than an entheseal origin for SpA could change our understanding of the disease pathogenesis and the relevant therapeutic approach.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Università degli studi della Campania Luigi Vanvitelli IT Italy (IT) Ospedale San Giovanni Bosco IT Italy (IT) University of Alberta CA Canada (CA)

How to cite

APA:

Mauro, D., Gandolfo, S., Tirri, E., Schett, G., Maksymowych, W.P., & Ciccia, F. (2023). The bone marrow side of axial spondyloarthritis. Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-023-00986-6

MLA:

Mauro, Daniele, et al. "The bone marrow side of axial spondyloarthritis." Nature Reviews Rheumatology (2023).

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