FcγRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease
Raaz D, Herrmann M, Ekici AB, Klinghammer L, Lausen B, Voll RE, Leusen JH, van de Winkel JG, Daniel W, Reis A, Garlichs C (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 205
Pages Range: 512-516
Journal Issue: 2
DOI: 10.1016/j.atherosclerosis.2009.01.013
Abstract
Objective: Identification of clinically relevant determinants for acute coronary syndromes (ACS) promises reduction of ACS-associated mortality. C-reactive protein (CRP) has proved to be useful identifying people at risk for cardiovascular events. However, it is unknown whether genetic variants at Fcγ receptor IIa (FcγRIIa), the main receptor for CRP, are involved in CRP-related cardiovascular risk. We evaluated the potential impact of FcγRIIa through a genetic association study in patients with ACS. Methods and results: We conducted a genetic association study among 701 consecutive patients with first event of ACS compared to 467 patients with stable angina pectoris. All patients were genotyped for a frequent functional variant at position 131 of the mature FcγRIIa, where the arginine (R) allele results in an increased signal transduction upon CRP binding. In our study, the R/R131 genotype was significantly associated with ACS as the first manifestation of coronary artery disease (P = 1.2 × 10-9, odds ratio 2.86, 95% CI: 2.06-3.99) compared to the non-R/R131 genotype. Conclusions: Our data show a genetic association of the FcγRIIa R/R131 genotype with a more frequent occurrence of ACS as the first manifestation of coronary artery disease, probably mediated via its interaction with CRP. Genotyping of this FcγRIIa variant could help to improve risk stratification in the course of coronary disease in the future. © 2009 Elsevier Ireland Ltd. All rights reserved.
Authors with CRIS profile
Dorette Raaz-Schrauder
Department of Medicine 2 – Cardiology and Angiology
Martin Herrmann
Department of Medicine 3 – Rheumatology and Immunology
Arif Bülent Ekici
Institute of Human Genetics
Lutz Klinghammer
Department of Medicine 2 – Cardiology and Angiology
Berthold Lausen
Medizinische Fakultät
Werner Daniel
Medizinische Fakultät
André Wiesmann da Silva Reis
Lehrstuhl für Humangenetik
Christoph Garlichs
Medizinische Fakultät
Involved external institutions
Netherlands (NL)How to cite
APA:
Raaz, D., Herrmann, M., Ekici, A.B., Klinghammer, L., Lausen, B., Voll, R.E.,... Garlichs, C. (2009). FcγRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease. Atherosclerosis, 205(2), 512-516. https://doi.org/10.1016/j.atherosclerosis.2009.01.013
MLA:
Raaz, Dorette, et al. "FcγRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease." Atherosclerosis 205.2 (2009): 512-516.
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