Doskaliuk B, Ravichandran N, Sen P, Day J, Joshi M, Nune A, Nikiphorou E, Saha S, Tan AL, Shinjo SK, Ziade N, Velikova T, Milchert M, Jagtap K, Parodis I, Gracia-Ramos AE, Cavagna L, Kuwana M, Knitza J, Chen YM, Makol A, Agarwal V, Patel A, Pauling JD, Wincup C, Barman B, Tehozol EAZ, Serrano JR, La Torre IGD, Colunga-Pedraza IJ, Merayo-Chalico J, Chibuzo OC, Katchamart W, Goo PA, Shumnalieva R, Hoff LS, Kibbi LE, Halabi H, Vaidya B, Shaharir SS, Hasan AT, Dey D, Gutiérrez CET, Caballero-Uribe CV, Lilleker JB, Salim B, Gheita T, Chatterjee T, Distler O, Saavedra MA, Kardes S, Andreoli L, Lini D, Schreiber K, Vince MN, Singh YP, Ranjan R, Jain A, Pandya SC, Pilania RK, Sharma A, Manesh Manoj M, Gupta V, Kavadichanda CG, Patro PS, Ajmani S, Phatak S, Goswami RP, Chowdhury AC, Mathew AJ, Shenoy P, Asranna A, Bommakanti KT, Shukla A, Pande AR, Chandwar K, Ghodke A, Boro H, Fazal ZZ, Cansu DÜ, Yıldırım R, Del PapaSambataro AYGNG, Fabiola A, Parisi MGS, Bocci EB, Sebastiani GD, Fusaro E, Quartuccio MSL, Franceschini F, Orsolini PPSG, De AngelisVenerito RMGDV, Grignaschi S, Giollo A, Alluno A, Ioannone F, Fornaro M, Traboco LS, Wibowo SAK, Loarce-Martos J, Prieto-González S, Gonzalez RA, Yoshida A, Nakashima R, Sato S, Kimura N, Kaneko Y, Gono T, Tomaras S, Proft FN, Holzer MT, Gromova MA, Aharonov O, Griger Z, Hmamouchi I, bouchti IE, Baba Z, Giannini M, Maurier F, Campagne J, Meyer A, Langguth D, Limaye V, Needham M, Srivastav N, Landon-Cardinal MHO, Zuleta WGR, Cajas ÁAJ, Silva JAP, Fonseca JE, Bohdana OZD, Ima-Edomwonyi U, Dedeke I, Airenakho E, Madu NH, Yerima A, Olaosebikan H, Becky A, Koussougbo OD, Palalane E, So H, Ugarte-Gil MF, Chinchay L, Bernaola JP, Pimentel V, Fathi HM, Mohammed RHA, Harifi G, Cabriza YFSK, Losanto J, Colaman N, Cachafeiro-Vilar A, Bautista GG, Ho EJG, Nunez LS, Cristian Vergara M, Báez JT, Alonzo H, Pastelin CBS, Salinas RG, Obiols AQ, Chávez N, Ordóñez AB, Llerena GAR, Sierra-Zorita R, Arrieta D, Hidalgo ER, Saenz R, Idania Escalante M, Calapaqui W, Quezada I, Arredondo G, Chinoy H, Agarwal V, Aggarwal R, Gupta L (2023)
Publication Type: Journal article
Publication year: 2023
DOI: 10.1007/s00296-023-05345-y
Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute to vaccine hesitancy. We studied delayed-onset vaccine adverse events (AEs) in patients with IIMs, other systemic autoimmune and inflammatory disorders (SAIDs), and healthy controls (HCs), using data from the second COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by the COVAD study group (157 collaborators, 106 countries) from Feb–June 2022. We collected data on demographics, comorbidities, IIM/SAID details, COVID-19 history, and vaccination details. Delayed-onset (> 7 day) AEs were analyzed using regression models. A total of 15165 respondents undertook the survey, of whom 8759 responses from vaccinated individuals [median age 46 (35–58) years, 74.4% females, 45.4% Caucasians] were analyzed. Of these, 1390 (15.9%) had IIMs, 50.6% other SAIDs, and 33.5% HCs. Among IIMs, 16.3% and 10.2% patients reported minor and major AEs, respectively, and 0.72% (n = 10) required hospitalization. Notably patients with IIMs experienced fewer minor AEs than other SAIDs, though rashes were expectedly more than HCs [OR 4.0; 95% CI 2.2–7.0, p < 0.001]. IIM patients with active disease, overlap myositis, autoimmune comorbidities, and ChadOx1 nCOV-19 (Oxford/AstraZeneca) recipients reported AEs more often, while those with inclusion body myositis, and BNT162b2 (Pfizer) recipients reported fewer AEs. Vaccination is reassuringly safe in individuals with IIMs, with AEs, hospitalizations comparable to SAIDs, and largely limited to those with autoimmune multimorbidity and active disease. These observations may inform guidelines to identify high-risk patients warranting close monitoring in the post-vaccination period.
APA:
Doskaliuk, B., Ravichandran, N., Sen, P., Day, J., Joshi, M., Nune, A.,... Gupta, L. (2023). Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study. Rheumatology International. https://doi.org/10.1007/s00296-023-05345-y
MLA:
Doskaliuk, Bohdana, et al. "Long-term safety of COVID vaccination in individuals with idiopathic inflammatory myopathies: results from the COVAD study." Rheumatology International (2023).
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