High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey

Grignaschi S, Kim M, Zanframundo G, Ravichandran N, Lilleker JB, Sen P, Joshi M, Agarwal V, Kardes S, Day J, Makol A, Milchert M, Gheita T, Salim B, Velikova T, Gracia-Ramos AE, Parodis I, Nikiphorou E, Chatterjee T, Tan AL, Saavedra MA, Shinjo SK, Ziade N, Knitza J, Kuwana M, Nune A, Distler O, Chinoy H, Cavagna L, Agarwal V, Aggarwal R, Gupta L, Barman B, Singh YP, Ranjan R, Jain A, Pandya SC, Pilania RK, Sharma A, Manoj MM, Gupta V, Kavadichanda CG, Patro PS, Ajmani S, Phatak S, Goswami RP, Chowdhury AC, Mathew AJ, Shenoy P, Asranna A, Bommakanti KT, Shukla A, Pande AR, Chandwar K, Cansu DÜ, Pauling JD, Wincup C, Papa ND, Sambataro G, Fabiola A, Govoni M, Parisi S, Bocci EB, Sebastiani GD, Fusaro E, Sebastiani M, Quartuccio L, Franceschini F, Sainaghi PP, Orsolini G, De Angelis R, Danielli MG, Venerito V, Traboco LS, Wibowo SAK, Serrano JR, Torre IGDL, Tehozol EAZ, Loarce-Martos J, Prieto-González S, Gonzalez RA, Yoshida A, Nakashima R, Sato S, Kimura N, Kaneko Y, Tomaras S, Gromova MA, Aharonov O, Hmamouchi I, Hoff LS, Giannini M, Maurier F, Campagne J, Meyer A, Nagy-Vincze M, Langguth D, Limaye V, Needham M, Srivastav N, Hudson M, Landon-Cardinal O, Shaharir SS, Zuleta WGR, Silva JAP, Fonseca JE (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1007/s00296-023-05344-z

Abstract

Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze differences in visual analog scale (VAS) scores (0–10 cm) for fatigue (VAS-F) in patients with IIMs, non-IIM systemic autoimmune diseases (SAIDs), and healthy controls (HCs). We performed a cross-sectional analysis of the data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) international patient self-reported e-survey. The COVAD survey was circulated from December 2020 to August 2021, and details including demographics, COVID-19 history, vaccination details, SAID details, global health, and functional status were collected from adult patients having received at least one COVID-19 vaccine dose. Fatigue experienced 1 week prior to survey completion was assessed using a single-item 10 cm VAS. Determinants of fatigue were analyzed in regression models. Six thousand nine hundred and eighty-eight respondents (mean age 43.8 years, 72% female; 55% White) were included in the analysis. The overall VAS-F score was 3 (IQR 1–6). Patients with IIMs had similar fatigue scores (5, IQR 3–7) to non-IIM SAIDs [5 (IQR 2–7)], but higher compared to HCs (2, IQR 1–5; P < 0.001), regardless of disease activity. In adjusted analysis, higher VAS-F scores were seen in females (reference female; coefficient −0.17; 95%CI −0.21 to −13; P < 0.001) and Caucasians (reference Caucasians; coefficient −0.22; 95%CI −0.30 to −0.14; P < 0.001 for Asians and coefficient −0.08; 95%CI −0.13 to 0.30; P = 0.003 for Hispanics) in our cohort. Our study found that patients with IIMs exhibit considerable fatigue, similar to other SAIDs and higher than healthy individuals. Women and Caucasians experience greater fatigue scores, allowing identification of stratified groups for optimized multidisciplinary care and improve outcomes such as quality of life.

Authors with CRIS profile

Involved external institutions

Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Universitätsspital Zürich (USZ) Switzerland (CH) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) University of Pittsburgh United States (USA) (US) Byramjee Jeejeebhoy Government Medical College & Sassoon General Hospital India (IN) Mahatma Gandhi Mission Medical College and Hospital India (IN) Istanbul University / İstanbul Üniversitesi Turkey (TR) Fauji Foundation Hospital Pakistan (PK) Sofia University "St. Kliment Ohridski" / Софийски университет "Св. Климент Охридски" Bulgaria (BG) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) University of Illinois at Chicago United States (USA) (US) NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU) United Kingdom (GB) Centro Medico Nacional Siglo XXI Mexico (MX) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB) Università degli Studi di Pavia Italy (IT) Policlinico San Matteo Pavia Fondazione IRCCS Italy (IT) University of Manchester United Kingdom (GB) Maulana Azad Medical College (MAMC) India (IN) Royal Melbourne Hospital (RMH) Australia (AU) Mayo Clinic United States (USA) (US) Instituto Mexicano del Seguro Social Mexico (MX) King's College Hospital (KCH) United Kingdom (GB) Southport and Ormskirk Hospital NHS Trust United Kingdom (GB)

How to cite

APA:

Grignaschi, S., Kim, M., Zanframundo, G., Ravichandran, N., Lilleker, J.B., Sen, P.,... Fonseca, J.E. (2023). High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey. Rheumatology International. https://dx.doi.org/10.1007/s00296-023-05344-z

MLA:

Grignaschi, Silvia, et al. "High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey." Rheumatology International (2023).

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