Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited]

Hwang Y, Won J, Yaghy A, Takahashi H, Girgis JM, Lam K, Chen S, Moult EM, Ploner S, Maier A, Waheed NK, Fujimoto JG (2023)


Publication Type: Journal article, Original article

Publication year: 2023

Journal

Book Volume: 14

Pages Range: 2658-2677

Journal Issue: 6

DOI: 10.1364/BOE.488103

Abstract

Optical coherence tomography angiography (OCTA) can visualize vasculature structures, but provides limited information about blood flow speed. Here, we present a second generation variable interscan time analysis (VISTA) OCTA, which evaluates a quantitative surrogate marker for blood flow speed in vasculature. At the capillary level, spatially compiled OCTA and a simple temporal autocorrelation model, ρ(τ) = exp(-ατ), were used to evaluate a temporal autocorrelation decay constant, α, as the blood flow speed marker. A 600 kHz A-scan rate swept-source OCT prototype instrument provides short interscan time OCTA and fine A-scan spacing acquisition, while maintaining multi mm2 field of views for human retinal imaging. We demonstrate the cardiac pulsatility and assess repeatability of α measured with VISTA. We show different α for different retinal capillary plexuses in healthy eyes and present representative VISTA OCTA in eyes with diabetic retinopathy.

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How to cite

APA:

Hwang, Y., Won, J., Yaghy, A., Takahashi, H., Girgis, J.M., Lam, K.,... Fujimoto, J.G. (2023). Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited]. Biomedical Optics Express, 14(6), 2658-2677. https://dx.doi.org/10.1364/BOE.488103

MLA:

Hwang, Yunchan, et al. "Retinal blood flow speed quantification at the capillary level using temporal autocorrelation fitting OCTA [Invited]." Biomedical Optics Express 14.6 (2023): 2658-2677.

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