M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch

Torow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Immunity Elsevier

Book Volume: 56

Pages Range: 1220-1238.e7

Journal Issue: 6

DOI: 10.1016/j.immuni.2023.04.002

Abstract

Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), the primary inductive site of intestinal immunity. Conventional type 1 and 2 dendritic cells (cDC1 and cDC2) and RORgt+ antigen-presenting cells (RORgt+ APC) exhibited significant age-dependent changes in subset composition, tissue distribution, and reduced cell maturation, subsequently resulting in a lack in CD4+ T cell priming during the postnatal period. Microbial cues contributed but could not fully explain the discrepancies in MNP maturation. Type I interferon (IFN) accelerated MNP maturation but IFN signaling did not represent the physiological stimulus. Instead, follicle-associated epithelium (FAE) M cell differentiation was required and sufficient to drive postweaning PP MNP maturation. Together, our results highlight the role of FAE M cell differentiation and MNP maturation in postnatal immune development.

Authors with CRIS profile

Stephan Patrick Rosshart Professur für Mikrobiomik

Involved external institutions

Universitätsklinikum Aachen (UKA) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Helmholtz-Zentrum für Umweltforschung (UFZ) / Helmholtz Center for Environmental Research DE Germany (DE) Immunology Center of Marseille-Luminy FR France (FR) University of Pittsburgh Medical Center (UPMC) US United States (USA) (US) Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE)

How to cite

APA:

Torow, N., Li, R., Hitch, T.C.A., Mingels, C., Al Bounny, S., van Best, N.,... Hornef, M.W. (2023). M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch. Immunity, 56(6), 1220-1238.e7. https://dx.doi.org/10.1016/j.immuni.2023.04.002

MLA:

Torow, Natalia, et al. "M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch." Immunity 56.6 (2023): 1220-1238.e7.

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