Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma

Zundler S, Vitali F, Kharboutli S, Völkl S, Polifka I, Mackensen A, Atreya R, Neurath M, Mougiakakos D (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Frontiers in Oncology Frontiers Media

Book Volume: 13

Article Number: 1149450

DOI: 10.3389/fonc.2023.1149450

Abstract

Chimeric antigen receptor (CAR) T cell therapy has become a new mainstay in the treatment of several hematologic malignancies, but the spectrum of associated complications is still incompletely defined. Here, we report the case of a 70-year-old female patient treated with tisagenlecleucel for diffuse large B cell lymphoma (DLBCL), who developed chronic diarrhea with characteristics of inflammatory bowel disease (IBD)-like colitis. CAR T cells were substantially enriched in the colon lamina propria and other diagnoses were ruled out. Thus, we conclude that IBD-like colitis in this patient was associated to CAR T cell therapy and needs to be considered as a rare potential complication.

Authors with CRIS profile

Sebastian Zundler Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Francesco Vitali Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Soraya Kharboutli Medizinische Fakultät Simon Völkl Department of Medicine 5 – Haematology and Oncology Iris Polifka Institute of Pathology Andreas Mackensen Lehrstuhl für Innere Medizin V Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur) Markus Neurath Lehrstuhl für Innere Medizin I Dimitrios Mougiakakos Professur für Hämatologie mit dem Schwerpunkt Zelluläre Immuntherapie

How to cite

APA:

Zundler, S., Vitali, F., Kharboutli, S., Völkl, S., Polifka, I., Mackensen, A.,... Mougiakakos, D. (2023). Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma. Frontiers in Oncology, 13. https://doi.org/10.3389/fonc.2023.1149450

MLA:

Zundler, Sebastian, et al. "Case Report: IBD-like colitis following CAR T cell therapy for diffuse large B cell lymphoma." Frontiers in Oncology 13 (2023).

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