Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies
Brokmeier LL, Firth J, Vancampfort D, Smith L, Deenik J, Rosenbaum S, Stubbs B, Schuch FB (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 284
Article Number: 112675
DOI: 10.1016/j.psychres.2019.112675
Abstract
Longitudinal prospective cohorts have suggested that physical activity (PA) may be a protective factor against psychosis and schizophrenia. However, no meta-analysis has been conducted. The study aims to examine the prospective relationship between PA and incident psychosis/schizophrenia. Major databases were searched from inception to July 2019 for prospective studies that calculated the odds ratio (OR) or the adjusted odds ratio (AOR) of incident psychosis/schizophrenia in people with higher PA against people with lower PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted, for OR and AOR, separately. Across 4 cohorts (N = 30,025 median males = 50%, median follow-up = 32 years), people with high self-reported PA (versus low PA) were at reduced odds of developing psychosis/schizophrenia (OR = 0.73, 95%CI 0.532 to 0.995, p = 0.047). Analysis including 2 cohorts presenting AOR were not statistically significant (AOR = 0.59, 95%CI 0.253 to 1.383, p = 0.226). Overall study quality was high (mean NOS = 7.0). The literature on the topic is scarce, whilst crude analysis suggests that PA may be a protective factor against the emergence of psychosis/schizophrenia, but when adjusting for covariates, the association is no longer significant. Further studies with objective physical activity and adjustment for confounders are needed.
Authors with CRIS profile
Involved external institutions
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
GGz centraal
Netherlands (NL)
University of New South Wales (UNSW)
Australia (AU)
NICM Health Research Institute
Australia (AU)
Anglia Ruskin University
United Kingdom (GB)
Universität Konstanz
Germany (DE)
South London and Maudsley NHS Foundation Trust
United Kingdom (GB)
Federal University of Santa Maria / Universidade Federal de Santa Maria (UFSM)
Brazil (BR)
Belgium (BE)
GGz centraal
Netherlands (NL)
University of New South Wales (UNSW)
Australia (AU)
NICM Health Research Institute
Australia (AU)
Anglia Ruskin University
United Kingdom (GB)
Universität Konstanz
Germany (DE)
South London and Maudsley NHS Foundation Trust
United Kingdom (GB)
Federal University of Santa Maria / Universidade Federal de Santa Maria (UFSM)
Brazil (BR)
How to cite
APA:
Brokmeier, L.L., Firth, J., Vancampfort, D., Smith, L., Deenik, J., Rosenbaum, S.,... Schuch, F.B. (2020). Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies. Psychiatry Research, 284. https://doi.org/10.1016/j.psychres.2019.112675
MLA:
Brokmeier, Luisa Leonie, et al. "Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies." Psychiatry Research 284 (2020).
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