IgG4-related sclerosing thyroiditis (Riedel-Struma): a review of clinicopathological features and management

Czarnywojtek A, Pietronczyk K, Thompson LDR, Triantafyllou A, Florek E, Sawicka-Gutaj N, Ruchala M, Plazinska MT, Nixon IJ, Shaha AR, Zafereo M, Randolph GW, Angelos P, Al Ghuzlan A, Agaimy A, Ferlito A (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Virchows Archiv Springer Verlag (Germany)

DOI: 10.1007/s00428-023-03561-2

Abstract

We present a thorough review of the literature on Riedel thyroiditis (RT) with emphasis on aetiology, diagnosis and management, using the PubMed, Sinomed, and China National Knowledge Infrastructure databases. Although the exact aetiology of RT remains obscure, the histopathological features are consistent with a localized form of IgG(4)-related systemic disease (IgG(4)-RSD). Nevertheless, IgG4-RSD as a systemic fibroinflammatory disorder per se rarely affects the thyroid in the context of multiorgan manifestations. The initial diagnosis of RT is based on clinical history and imaging, but confirmation by histopathological examination is mandatory. In contrast to the historical surgical approach, glucocorticosteroid therapy is currently considered first line therapy, in line with the RT currently being viewed as a manifestation of, or analogous to, IgG4-RSD. For disease relapse, immunomodulatory agents (azathioprine, methotrexate, rituximab) can be used.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

University of Chicago US United States (USA) (US) The University of Liverpool GB United Kingdom (GB) Wrocław Medical University / Uniwersytet Medyczny we Wrocławiu PL Poland (PL) Poznan University of Medical Sciences / Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu PL Poland (PL) Memorial Sloan Kettering Cancer Center US United States (USA) (US) Harvard University US United States (USA) (US) NHS Lothian GB United Kingdom (GB) University of Texas MD Anderson Cancer Center US United States (USA) (US) Woodland Hills Medical Center US United States (USA) (US) International Head and Neck Scientific Group DE Germany (DE) École Polytechnique - Université Paris-Saclay FR France (FR)

How to cite

APA:

Czarnywojtek, A., Pietronczyk, K., Thompson, L.D.R., Triantafyllou, A., Florek, E., Sawicka-Gutaj, N.,... Ferlito, A. (2023). IgG4-related sclerosing thyroiditis (Riedel-Struma): a review of clinicopathological features and management. Virchows Archiv. https://dx.doi.org/10.1007/s00428-023-03561-2

MLA:

Czarnywojtek, Agata, et al. "IgG4-related sclerosing thyroiditis (Riedel-Struma): a review of clinicopathological features and management." Virchows Archiv (2023).

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