Biomaterial strategies to combat implant infections: new perspectives to old challenges
Braem A, Kamarudin NHN, Bhaskar N, Hadzhieva Z, Mele A, Soulie J, Linklater DP, Bonilla-Gameros L, Boccaccini AR, Roy I, Drouet C, Ivanova EP, Mantovani D, Basu B (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Journal
DOI: 10.1080/09506608.2023.2193784
Abstract
Peri-implant infection is rapidly becoming an - if not the most - important clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies.
Authors with CRIS profile
Zoya Hadzhieva
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Indian Institute of Science (IISc)
India (IN)
University of Sheffield
United Kingdom (GB)
Université Fédérale de Toulouse Midi-Pyrénées
France (FR)
Royal Melbourne Institute of Technology (RMIT)
Australia (AU)
Université Laval (UL)
Canada (CA)
Belgium (BE)
Indian Institute of Science (IISc)
India (IN)
University of Sheffield
United Kingdom (GB)
Université Fédérale de Toulouse Midi-Pyrénées
France (FR)
Royal Melbourne Institute of Technology (RMIT)
Australia (AU)
Université Laval (UL)
Canada (CA)
How to cite
APA:
Braem, A., Kamarudin, N.H.N., Bhaskar, N., Hadzhieva, Z., Mele, A., Soulie, J.,... Basu, B. (2023). Biomaterial strategies to combat implant infections: new perspectives to old challenges. International Materials Reviews. https://doi.org/10.1080/09506608.2023.2193784
MLA:
Braem, Annabel, et al. "Biomaterial strategies to combat implant infections: new perspectives to old challenges." International Materials Reviews (2023).
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