Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety

Unterweger H, Janko C, Folk T, Cicha I, Kovacs N, Gyebnar G, Horvath I, Mathe D, Zheng KH, Coolen BF, Stroes E, Szebeni J, Alexiou C, Dezsi L, Lyer S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

International Journal of Nanomedicine Dove Medical Press

Book Volume: 18

Pages Range: 2071-2086

DOI: 10.2147/IJN.S402320

Abstract

Introduction: One of the major challenges in the clinical translation of nanoparticles is the development of formulations combining favorable efficacy and optimal safety. In the past, iron oxide nanoparticles have been introduced as an alternative for gadolinium-containing contrast agents; however, candidates available at the time were not free from adverse effects. Methods: Following the development of a potent iron oxide-based contrast agent SPION^Dex, we now performed a systematic comparison of this formulation with the conventional contrast agent ferucarbotran and with ferumoxytol, taking into consideration their physicochemical characteristics, bio-and hemocompatibility in vitro and in vivo, as well as their liver imaging properties in rats. Results: The results demonstrated superior in vitro cyto-, hemo-and immunocompatibility of SPION^Dex in comparison to the other two formulations. Intravenous administration of ferucarbotran or ferumoxytol induced strong complement activation-related pseu-doallergy in pigs. In contrast, SPION^Dex did not elicit any hypersensitivity reactions in the experimental animals. In a rat model, comparable liver imaging properties, but a faster clearance was demonstrated for SPION^Dex. Conclusion: The results indicate that SPION^Dex possess an exceptional safety compared to the other two formulations, making them a promising candidate for further clinical translation.

Authors with CRIS profile

Harald Unterweger Department of Otorhinolaryngology – Head and Neck Surgery Christina Janko Department of Otorhinolaryngology – Head and Neck Surgery Iwona Cicha Medizinische Fakultät Christoph Alexiou Professur für Nanomedizin Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery

Involved external institutions

University of Amsterdam

Netherlands (NL) Semmelweis University / Semmelweis Egyetem

Hungary (HU)

How to cite

APA:

Unterweger, H., Janko, C., Folk, T., Cicha, I., Kovacs, N., Gyebnar, G.,... Lyer, S. (2023). Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety. International Journal of Nanomedicine, 18, 2071-2086. https://doi.org/10.2147/IJN.S402320

MLA:

Unterweger, Harald, et al. "Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety." International Journal of Nanomedicine 18 (2023): 2071-2086.

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