Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use
Weber D, Weber M, Meedt E, Ghimire S, Wolff D, Edinger M, Poeck H, Hiergeist A, Gessner A, Ayuk F, Rösler W, Wölfl M, Kraus S, Zeiser R, Bertrand H, Bader P, Ullrich E, Eder M, Gleich S, Young R, Herr W, Levine JE, Ferrara JL, Holler E (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 7
Pages Range: 1326-1335
Journal Issue: 7
DOI: 10.1182/bloodadvances.2022008480
Abstract
Intestinal microbiome diversity plays an important role in the pathophysiology of acute gastrointestinal (GI) graft-versus-host disease (GVHD) and influences the outcome of patients after allogeneic stem cell transplantation (ASCT). We analyzed clinical data and blood samples taken preconditioning and on the day of ASCT from 587 patients from 7 German centers of the Mount Sinai Acute GVHD International Consortium, dividing them into single-center test (n = 371) and multicenter validation (n = 216) cohorts. Regenerating islet–derived 3α (Reg3α) serum concentration of day 0 correlated with clinical data as well as urinary 3-indoxylsulfate (3-IS) and Clostridiales group XIVa, indicators of intestinal microbiome diversity. High Reg3α concentration at day 0 of ASCT was associated with higher 1-year transplant-related mortality (TRM) in both cohorts (P < .001). Cox regression analysis revealed high Reg3α at day 0 as an independent prognostic factor for 1-year TRM. Multivariable analysis showed an independent correlation of high Reg3α concentrations at day 0 with early systemic antibiotic (AB) treatment. Urinary 3-IS (P = .04) and Clostridiales group XIVa (P = .004) were lower in patients with high vs those with low day 0 Reg3α concentrations. In contrast, Reg3α concentrations before conditioning therapy correlated neither with TRM nor disease or treatment-related parameters. Reg3α, a known biomarker of acute GI GVHD correlates with intestinal dysbiosis, induced by early AB treatment in the period of pretransplant conditioning. Serum concentrations of Reg3α measured on the day of graft infusion are predictive of the risk for TRM of ASCT recipients.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Regensburg
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Universitätsklinikum Freiburg
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Icahn School of Medicine at Mount Sinai
United States (USA) (US)
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Universitätsklinikum Freiburg
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Icahn School of Medicine at Mount Sinai
United States (USA) (US)
How to cite
APA:
Weber, D., Weber, M., Meedt, E., Ghimire, S., Wolff, D., Edinger, M.,... Holler, E. (2023). Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use. Blood Advances, 7(7), 1326-1335. https://doi.org/10.1182/bloodadvances.2022008480
MLA:
Weber, Daniela, et al. "Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use." Blood Advances 7.7 (2023): 1326-1335.
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