SOLVe: a closed-loop system focused on protective mechanical ventilation
von Platen P, Pickerodt PA, Russ M, Taher M, Hinken L, Braun W, Köbrich R, Pomprapa A, Francis RCE, Leonhardt S, Walter M (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 22
Pages Range: 47-
Journal Issue: 1
DOI: 10.1186/s12938-023-01111-0
Abstract
BACKGROUND: Mechanical ventilation is an essential component in the treatment of patients with acute respiratory distress syndrome. Prompt adaptation of the settings of a ventilator to the variable needs of patients is essential to ensure personalised and protective ventilation. Still, it is challenging and time-consuming for the therapist at the bedside. In addition, general implementation barriers hinder the timely incorporation of new evidence from clinical studies into routine clinical practice. RESULTS: We present a system combing clinical evidence and expert knowledge within a physiological closed-loop control structure for mechanical ventilation. The system includes multiple controllers to support adequate gas exchange while adhering to multiple evidence-based components of lung protective ventilation. We performed a pilot study on three animals with an induced ARDS. The system achieved a time-in-target of over 75 % for all targets and avoided any critical phases of low oxygen saturation, despite provoked disturbances such as disconnections from the ventilator and positional changes of the subject. CONCLUSIONS: The presented system can provide personalised and lung-protective ventilation and reduce clinician workload in clinical practice.
Authors with CRIS profile
Involved external institutions
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Fritz Stephan GmbH
Germany (DE)
EKU Elektronik GmbH
Germany (DE)
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Fritz Stephan GmbH
Germany (DE)
EKU Elektronik GmbH
Germany (DE)
How to cite
APA:
von Platen, P., Pickerodt, P.A., Russ, M., Taher, M., Hinken, L., Braun, W.,... Walter, M. (2023). SOLVe: a closed-loop system focused on protective mechanical ventilation. Biomedical Engineering Online, 22(1), 47-. https://dx.doi.org/10.1186/s12938-023-01111-0
MLA:
von Platen, Philip, et al. "SOLVe: a closed-loop system focused on protective mechanical ventilation." Biomedical Engineering Online 22.1 (2023): 47-.
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