Free-Breathing Liver Fat, R∗ and B Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction

Tan Z, Unterberg-Buchwald C, Blumenthal M, Scholand N, Schaten P, Holme C, Wang X, Raddatz D, Uecker M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

IEEE Transactions on Medical Imaging Institute of Electrical and Electronics Engineers (IEEE)

Book Volume: 42

Pages Range: 1374-1387

Journal Issue: 5

DOI: 10.1109/TMI.2022.3228075

Abstract

This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition. Regularized model-based reconstruction was implemented in Berkeley Advanced Reconstruction Toolbox (BART) to jointly estimate all physical parameter maps (water, fat, R2∗ , and B0 field inhomogeneity maps) and coil sensitivity maps from self-gated κ-space data. Specifically, locally low rank and temporal total variation regularization were employed directly on physical parameter maps. The proposed free-breathing radial technique was tested on a water/fat & iron phantom, a young volunteer, and obesity/diabetes/hepatic steatosis patients. Quantitative fat fraction and R2∗ accuracy were confirmed by comparing our technique with the reference breath-hold Cartesian scan. The multi-echo radial sampling sequence achieves fast κ-space coverage and is robust to motion. Moreover, the proposed motion-resolved model-based reconstruction allows for free-breathing liver fat and R2∗ quantification in multiple motion states. Overall, our proposed technique offers a convenient tool for non-invasive liver assessment with no breath holding requirement.

Involved external institutions

Universitätsklinikum Göttingen

Germany (DE) Technische Universität Graz

Austria (AT) Harvard University

United States (USA) (US)

How to cite

APA:

Tan, Z., Unterberg-Buchwald, C., Blumenthal, M., Scholand, N., Schaten, P., Holme, C.,... Uecker, M. (2023). Free-Breathing Liver Fat, R∗ and B Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction. IEEE Transactions on Medical Imaging, 42(5), 1374-1387. https://doi.org/10.1109/TMI.2022.3228075

MLA:

Tan, Zhengguo, et al. "Free-Breathing Liver Fat, R∗ and B Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction." IEEE Transactions on Medical Imaging 42.5 (2023): 1374-1387.

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