Free-Breathing Liver Fat, R∗ and B Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction

Tan Z, Unterberg-Buchwald C, Blumenthal M, Scholand N, Schaten P, Holme C, Wang X, Raddatz D, Uecker M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

IEEE Transactions on Medical Imaging Institute of Electrical and Electronics Engineers (IEEE)

Book Volume: 42

Pages Range: 1374-1387

Journal Issue: 5

DOI: 10.1109/TMI.2022.3228075

Abstract

This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition. Regularized model-based reconstruction was implemented in Berkeley Advanced Reconstruction Toolbox (BART) to jointly estimate all physical parameter maps (water, fat, R2∗ , and B0 field inhomogeneity maps) and coil sensitivity maps from self-gated κ-space data. Specifically, locally low rank and temporal total variation regularization were employed directly on physical parameter maps. The proposed free-breathing radial technique was tested on a water/fat & iron phantom, a young volunteer, and obesity/diabetes/hepatic steatosis patients. Quantitative fat fraction and R2∗ accuracy were confirmed by comparing our technique with the reference breath-hold Cartesian scan. The multi-echo radial sampling sequence achieves fast κ-space coverage and is robust to motion. Moreover, the proposed motion-resolved model-based reconstruction allows for free-breathing liver fat and R2∗ quantification in multiple motion states. Overall, our proposed technique offers a convenient tool for non-invasive liver assessment with no breath holding requirement.

Involved external institutions

Universitätsklinikum Göttingen DE Germany (DE) Technische Universität Graz AT Austria (AT) Veterans Affairs Healthcare System Boston and Harvard Medical School US United States (USA) (US)

How to cite

APA:

Tan, Z., Unterberg-Buchwald, C., Blumenthal, M., Scholand, N., Schaten, P., Holme, C.,... Uecker, M. (2023). Free-Breathing Liver Fat, R∗ and B Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction. IEEE Transactions on Medical Imaging, 42(5), 1374-1387. https://dx.doi.org/10.1109/TMI.2022.3228075

MLA:

Tan, Zhengguo, et al. "Free-Breathing Liver Fat, R∗ and B Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction." IEEE Transactions on Medical Imaging 42.5 (2023): 1374-1387.

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