Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment
David P, Mittelstädt A, Kouhestani D, Anthuber A, Kahlert C, Sohn K, Weber G (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Journal
Book Volume: 15
Article Number: 1924
Journal Issue: 7
Abstract
Worldwide, gastrointestinal (GI) cancers account for a significant amount of cancer-related mortality. Tests that allow an early diagnosis could lead to an improvement in patient survival. Liquid biopsies (LBs) due to their non-invasive nature as well as low risk are the current focus of cancer research and could be a promising tool for early cancer detection. LB involves the sampling of any biological fluid (e.g., blood, urine, saliva) to enrich and analyze the tumor’s biological material. LBs can detect tumor-associated components such as circulating tumor DNA (ctDNA), extracellular vesicles (EVs), and circulating tumor cells (CTCs). These components can reflect the status of the disease and can facilitate clinical decisions. LBs offer a unique and new way to assess cancers at all stages of treatment, from cancer screenings to prognosis to management of multidisciplinary therapies. In this review, we will provide insights into the current status of the various types of LBs enabling early detection and monitoring of GI cancers and their use in in vitro diagnostics.
Authors with CRIS profile
Paul David
Department of Surgery
Anke Mittelstädt
Department of Surgery
Dina Kouhestani
Department of Surgery
Georg Weber
Department of Surgery
Additional Organisation(s)
Involved external institutions
Universitätsklinikum Carl Gustav Carus Dresden
Germany (DE)
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB / Fraunhofer Institute for Interfacial Engineering and Biotechnology
Germany (DE)
Germany (DE)
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB / Fraunhofer Institute for Interfacial Engineering and Biotechnology
Germany (DE)
How to cite
APA:
David, P., Mittelstädt, A., Kouhestani, D., Anthuber, A., Kahlert, C., Sohn, K., & Weber, G. (2023). Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment. Cancers, 15(7). https://doi.org/10.3390/cancers15071924
MLA:
David, Paul, et al. "Current Applications of Liquid Biopsy in Gastrointestinal Cancer Disease—From Early Cancer Detection to Individualized Cancer Treatment." Cancers 15.7 (2023).
BibTeX: Download