Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma

Brandt A, Thiele B, Schultheiß C, Daetwyler E, Binder M (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Cancers MDPI

Book Volume: 15

Article Number: 2051

Journal Issue: 7

DOI: 10.3390/cancers15072051

Abstract

Tumors shed cell-free DNA (cfDNA) into the plasma. “Liquid biopsies” are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may be useful in patients with head and neck squamous cell carcinoma (HNSCC) due to genetic tumor heterogeneity and limitations in imaging sensitivity. However, there are technical challenges that need to be overcome for the widespread use of liquid biopsy in the clinical management of these patients. In this review, we discuss our current understanding of HNSCC genetics and the role of cfDNA genomic analyses as an emerging precision diagnostic tool.

Authors with CRIS profile

Anna Brandt Department of Medicine 5 – Haematology and Oncology

Involved external institutions

Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) Universitätsspital Basel CH Switzerland (CH)

How to cite

APA:

Brandt, A., Thiele, B., Schultheiß, C., Daetwyler, E., & Binder, M. (2023). Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma. Cancers, 15(7). https://dx.doi.org/10.3390/cancers15072051

MLA:

Brandt, Anna, et al. "Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma." Cancers 15.7 (2023).

BibTeX: Download