Identifying breast cancer patients at risk of relapse despite pathological complete response after neoadjuvant therapy

Huober J, van Mackelenbergh M, Schneeweiss A, Seither F, Blohmer JU, Denkert C, Tesch H, Hanusch C, Salat C, Rhiem K, Solbach C, Fasching P, Jackisch C, Reinisch M, Lederer B, Mehta K, Link T, Nekljudova V, Loibl S, Untch M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

npj Breast Cancer Nature Research

Book Volume: 9

Article Number: 23

Journal Issue: 1

DOI: 10.1038/s41523-023-00525-2

Abstract

This retrospective pooled analysis aims to identify factors predicting relapse despite a pathologic complete response (pCR) in patients with breast cancer (BC). 2066 patients with a pCR from five neoadjuvant GBG/AGO-B trials fulfill the inclusion criteria of this analysis. Primary endpoint is disease-free survival (DFS); secondary endpoints is distant DFS (DDFS) and overall survival (OS). After a median follow-up of 57.6 months, DFS is significantly worse for patients with positive lymph nodes (cN+ vs cN0 hazard ratio [HR] 1.94, 95%CI 1.48–2.54; p < 0.001). In patients with triple-negative tumors, lobular histology (lobular vs other HR 3.55, 95%CI 1.53–8.23; p = 0.003), and clinical nodal involvement (cN+ vs cN0 HR 2.45, 95%CI 1.59–3.79; p < 0.001) predict a higher risk of DFS events. Patients with HER2-positive cT3/4 tumors have a significantly higher risk of relapse (cT3/4 vs cT1 HR 2.07, 95%CI 1.06–4.03; p = 0.033). Initial tumor load and histological type predict relapse in patients with a pCR.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe

Involved external institutions

Universitätsklinikum Ulm DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg DE Germany (DE) GBG Forschungs GmbH (German Breast Group) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Philipps-Universität Marburg DE Germany (DE) Agaplesion Markus Krankenhaus DE Germany (DE) LMU Klinikum DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Sana Kliniken AG DE Germany (DE) Kliniken Essen-Mitte DE Germany (DE) Technische Universität Dresden DE Germany (DE) HELIOS Kliniken DE Germany (DE)

How to cite

APA:

Huober, J., van Mackelenbergh, M., Schneeweiss, A., Seither, F., Blohmer, J.U., Denkert, C.,... Untch, M. (2023). Identifying breast cancer patients at risk of relapse despite pathological complete response after neoadjuvant therapy. npj Breast Cancer, 9(1). https://dx.doi.org/10.1038/s41523-023-00525-2

MLA:

Huober, Jens, et al. "Identifying breast cancer patients at risk of relapse despite pathological complete response after neoadjuvant therapy." npj Breast Cancer 9.1 (2023).

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