Endoscopic fiber probe for nonlinear spectroscopic imaging

Lukic A, Dochow S, Bae H, Matz G, Latka I, Messerschmidt B, Schmitt M, Popp J (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Optica Optical Society of America

Book Volume: 4

Pages Range: 496-501

Journal Issue: 5

DOI: 10.1364/OPTICA.4.000496

Abstract

We present a compact multimodal fiber probe that enables the simultaneous recording of nonlinear imaging modalities like coherent anti-Stokes Raman scattering (CARS), second harmonic generation (SHG), and two-photon excited auto-fluorescence (TPEF) for biomedical applications. The probe is based on a gradient index lens design and a multi-core fiber supplying the excitation laser light. The multi-core fiber preserves the spatial relationship between the entrance and output; therefore, the laser scanning procedure can be shifted from the distal to the proximal end of the probe. No moving parts or electric power are required in situ. The generated sample signals can be collected in the backward (epi) direction and transferred to a detection setup with a multimode fiber integrated in the probe head. The first CARS/SHG/TPEF multimodal tissue images recorded with the introduced fiber probe will be presented.

Involved external institutions

Leibniz-Institut für Photonische Technologien e.V. DE Germany (DE) Friedrich-Schiller-Universität Jena DE Germany (DE) GRINTECH GmbH DE Germany (DE)

How to cite

APA:

Lukic, A., Dochow, S., Bae, H., Matz, G., Latka, I., Messerschmidt, B.,... Popp, J. (2017). Endoscopic fiber probe for nonlinear spectroscopic imaging. Optica, 4(5), 496-501. https://doi.org/10.1364/OPTICA.4.000496

MLA:

Lukic, Aleksandar, et al. "Endoscopic fiber probe for nonlinear spectroscopic imaging." Optica 4.5 (2017): 496-501.

BibTeX: Download