Invited Article: A rigid coherent anti-Stokes Raman scattering endoscope with high resolution and a large field of view

Zirak P, Matz G, Messerschmidt B, Meyer T, Schmitt M, Popp J, Uckermann O, Galli R, Kirsch M, Winterhalder MJ, Zumbusch A (2018)

Publication Type: Journal article

Publication year: 2018

Journal

APL Photonics American Institute of Physics (AIP)

Book Volume: 3

Article Number: 092409

Journal Issue: 9

DOI: 10.1063/1.5027182

Abstract

Nonlinear optical endoscopy is an attractive technique for biomedical imaging since it promises to give access to high resolution imaging in vivo. Among the various techniques used for endoscopic contrast generation, coherent anti-Stokes Raman scattering (CARS) is especially interesting. CARS endoscopy allows molecule specific imaging of unlabeled samples. In this contribution, we describe the design, implementation, and experimental characterization of a rigid, compact CARS endoscope with a spatial resolution of 750 nm over a field of view of roughly 250 μm. Omission of the relay optics and use of a gradient index lens specifically designed for this application allow one to realize these specifications in an endoscopic unit which is 2.2 mm wide over a length of 187 mm, making clinical applications during surgical interventions possible. Multimodal use of the endoscope is demonstrated with images of samples with neurosurgical relevance.

Involved external institutions

Universität Konstanz DE Germany (DE) GRINTECH GmbH DE Germany (DE) Leibniz-Institut für Photonische Technologien e.V. DE Germany (DE) Friedrich-Schiller-Universität Jena DE Germany (DE) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Zirak, P., Matz, G., Messerschmidt, B., Meyer, T., Schmitt, M., Popp, J.,... Zumbusch, A. (2018). Invited Article: A rigid coherent anti-Stokes Raman scattering endoscope with high resolution and a large field of view. APL Photonics, 3(9). https://doi.org/10.1063/1.5027182

MLA:

Zirak, P., et al. "Invited Article: A rigid coherent anti-Stokes Raman scattering endoscope with high resolution and a large field of view." APL Photonics 3.9 (2018).

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