Precise Encoding of Triple-Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application

Zhu W, Cai EL, Li HZ, Wang P, Shen AG, Popp J, Hu JM (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Angewandte Chemie International Edition Wiley

Book Volume: 60

Pages Range: 21846-21852

Journal Issue: 40

DOI: 10.1002/anie.202106136

Abstract

Stimulated Raman scattering (SRS) microscopy in combination with innovative tagging strategies offers great potential as a universal high-throughput biomedical imaging tool. Here, we report rationally tailored small molecular monomers containing triple-bond units with large Raman scattering cross-sections, which can be polymerized at the nanoscale for enhancement of SRS contrast with smaller but brighter optical nanotags with artificial fingerprint output. From this, a class of triple-bond rich polymer nanoparticles (NPs) was engineered by regulating the relative dosages of three chemically different triple-bond monomers in co-polymerization. The bonding strategy allowed for 15 spectrally distinguishable triple-bond combinations. These accurately structured nano molecular aggregates, rather than long-chain macromolecules, could establish a universal method for generating small-sized biological SRS imaging tags with high sensitivity for high-throughput multi-color biomedical imaging.

Involved external institutions

Wuhan University CN China (CN) Huazhong University of Science & Technology CN China (CN) Friedrich-Schiller-Universität Jena DE Germany (DE)

How to cite

APA:

Zhu, W., Cai, E.-L., Li, H.-Z., Wang, P., Shen, A.-G., Popp, J., & Hu, J.-M. (2021). Precise Encoding of Triple-Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application. Angewandte Chemie International Edition, 60(40), 21846-21852. https://doi.org/10.1002/anie.202106136

MLA:

Zhu, Wei, et al. "Precise Encoding of Triple-Bond Raman Scattering of Single Polymer Nanoparticles for Multiplexed Imaging Application." Angewandte Chemie International Edition 60.40 (2021): 21846-21852.

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