Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy
Gottschall T, Meyer-Zedler T, Eibl M, Pfeiffer T, Hakert H, Schmitt M, Huber R, Tünnermann A, Limpert J, Popp J (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 127
Pages Range: 2375-2380
Journal Issue: 11
Abstract
Coherent Raman scattering microscopy utilizing bioorthogonal tagging approaches like isotope or alkyne labeling allows for a targeted monitoring of spatial distribution and dynamics of small molecules of interest in cells, tissues, and other complex biological matrices. To fully exploit this approach in terms of real-time monitoring of several Raman tags, e.g., to study drug uptake dynamics, extremely fast tunable lasers are needed. Here, we present a laser concept without moving parts and fully electronically controlled for the quasi-simultaneous acquisition of coherent anti-Stokes Raman scattering images at multiple Raman resonances. The laser concept is based on the combination of a low noise and spectrally narrow Fourier domain mode-locked laser seeding a compact four wave mixing-based high-power fiber-based optical parametric amplifier.
Involved external institutions
Germany (DE)How to cite
APA:
Gottschall, T., Meyer-Zedler, T., Eibl, M., Pfeiffer, T., Hakert, H., Schmitt, M.,... Popp, J. (2023). Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy. Journal of Physical Chemistry B, 127(11), 2375-2380. https://dx.doi.org/10.1021/acs.jpcb.2c09115
MLA:
Gottschall, Thomas, et al. "Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy." Journal of Physical Chemistry B 127.11 (2023): 2375-2380.
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